Satoshi Ishiguro, Shigeki Arii, Kazunobu Monden, Yukito Adachi, Naomi Funaki, Hiroaki Higashitsuji, Shin‐Ichi Fujita, Masaharu Furutani, Masahiro Mise, Tadahiro Kitao, Toshio Nakamura, Fumitaka Ushikubi, Ken‐Ichi Nakamura, Shuh Narumiya, Katsuhiko Enomoto, Tousei Ohmura, Michio Mori, Masayuki Imamura – 1 November 1994 – The presence of the thromboxane A2 receptor in sinusoidal endothelial cells was investigated and its pathogenic role in endotoxin‐induced liver injury examined. The receptor was measured with a binding assay using a specific thromboxane A2 receptor antagonist, [3H]S‐145.

Teresa L. Wright, Harry Hollander, Xiang Pu, Michael J. Held, Peter Lipson, Stella Quan, Alan Polito, M. Michael Thaler, Peter Bacchetti, Bruce F. Scharschmidt – 1 November 1994 – Background: Limited information is available about the prevalence of hepatitis C virus in patients with human immunodeficiency virus in relation to specific risk factors or about the influence of hepatitis C virus coinfection on survival. This retrospective study addressed these questions.

Gianfranco Tappero, Gioacchino Natoli, Giovanni Anfossi, Floriano Rosina, Francesco Negro, Antonina Smedile, Ferruccio Bonino, Alberto Angeli, Robert H. Purcell, Professor Mario Rizzetto, Massimo Levrero – 1 November 1994 – The intrahepatic accumulation of the c‐myc protooncogene product was observed on immunoflourescence in each of six patients with chronic hepatitis delta virus infection who exhibited the hepatitis D antigen in their livers. The c‐myc product was stained in the same nuclei that contained the hepatitis D antigen.

Kirk Sperber – 1 November 1994

Alan F. Hofmann, James M. Crawford – 1 November 1994

Kenneth Jensen, Christian Gluud – 1 November 1994 – Drawing on data from a previously published literature survey on the clinical and experimental epidemiology of the Mallory body, we discuss current theories on its development in a pro et contra manner. Conclusions have been largely left open to the interpretations of the reader because many are still speculative. The main results of this study characterize Mallory bodies as stereotypical histological byproducts to diverse hepatic injuries (mostly alcohol associated) of questionable pathogenic importance.

Hiroaki Shimizu, Wei He, Ping Guo, Irena Dziadkoviec, Masaru Miyazaki, Rudolf E. Falk – 1 November 1994 – This study was designed to evaluate the use of serum hyaluronate as a marker of liver endothelial cell function after liver transplantation. We performed orthotopic liver transplantation in both isogeneic and allogeneic rejector models. After transplantation, hepatocyte function was assessed on the basis of serum ALT and total bilirubin levels, and liver endothelial cell function was judged on the basis of serum hyaluronate levels.

M. Sawkat Anwer – 1 November 1994 – Arginine vasopressin has been shown to activate the Na/H+ exchanger in hepatocytes by calcium/calmodulin‐dependent processes. Whether this activation also involves protein kinase C and is associated with changes in the intracellular pH setpoint was investigated in this study. Changes in pHi and intracellular Ca++ concentration were measured with the fluorescent probes BCECF and quin‐2, respectively. Intracellular pH recovery rate was calculated from timedependent changes in intracellular pH in hepatocytes acid‐loaded with sodium propionate.

Paolo Caraceni, Antonio Gasbarrini, Andreas Nussler, Mauricio Di Silvio, Fabio Bartoli, Andre B. Borle, David H. Van Thiel – 1 November 1994 – We performed this study to determine whether perfused isolated human and rat hepatocytes have different sensitivities to anoxia‐reoxygenation injury. Oxygen free radicals were detected by lucigenin‐enhanced chemiluminescence. Lipid peroxidation was assessed by measuring malondialdehyde release. Cell injury was evaluated by measuring lactate dehydrogenase release and trypan blue uptake.

Akihiro Tamori, Shuhel Nishiguchi, Tetsuo Kuroki, Shuichi Seki, Kenzo Kobayashi, Hiroaki Kinoshita, Shuzo Otani – 1 November 1994 – To evaluate the correlation between the polyamine metabolism and the degree of malignancy in hepatocellular carcinoma, we measured ornithine decarboxylase activity and polyamine concentrations in neoplastic tissue and adjacent noncancerous tissue from resected specimens of liver from 30 patients.