Martin Krüger, Hans Ludger Tillmann, Christian Trautwein, Ulrike Bode, Karl Oldhafer, Hansjörg Maschek, Klaus H. W. Böker, Christoph E. Broelsch, Rudolf Pichlmayr, Michael P. Manns – 1 July 1996 – Despite hepatitis B immunoprophylaxis hepatitis B virus (HBV) recurrence is a frequent and often fatal complication after orthotopic liver transplantation (OLT). The purine nucleoside analogues penciclovir and its oral form famciclovir (FCV) proved to be well tolerated and effective against herpes simplex and zoster virus infections.

L S Friedman – 1 July 1996

M Lekehal, D Pessayre, J M Lereau, C Moulis, I Fourasté, D Fau – 1 July 1996 – Several herbal remedies have produced hepatitis in humans. The medicinal plant, germander, was recalled after its use as an adjuvant to slimming diets resulted in an epidemic of hepatitis in France. We studied the hepatotoxicity of germander in isolated rat hepatocytes.

R H Moseley, H Takeda, L J Zugger – 1 July 1996 – Previous studies have demonstrated several pathways for the sinusoidal uptake of endogenous and exogenous organic cations, including two distinct organic cation:H+ exchanges and a separate carrier‐mediated system driven by the inside‐negative membrane potential. In this study, the driving force(s) for the uptake of the endogenous quaternary amine, choline, were determined in rat liver basolateral plasma membrane (blLPM) vesicles.

1 July 1996

K Preisegger, C Stumptner, D Riegelnegg, P C Brown, J A Silverman, S S Thorgeirsson, H Denk – 1 July 1996 – Mallory bodies (MBs) are characteristic morphological features of alcoholic hepatitis and are also found in other chronic liver disorders and hepatocellular neoplasms. MBs can be produced in mouse liver by chronic administration of the porphyrinogenic drugs griseofulvin (GF) and 3,5‐diethoxy‐carbonyl‐1,4‐dihydrocollidine (DDC). The mechanisms causing the formation of MBs are poorly understood, and the significance of MB formation during the course of liver disease remains unclear.

C Enrich, S Jäckle, R J Havel – 1 July 1996 – Rat liver endosomes contain one major high‐affinity calmodulin‐binding protein (CaMBP) that now has been identified as the polymeric immunoglobulin receptor (pIgR). In isolated endosomes pIgR was enriched in the receptor‐recycling compartment (RRC); lesser enrichment was found in ‘early’ endosome (CURL) and much less in ‘late’ endosome fractions (multivesicular bodies, MVB).

M A Desiderio, L Tacchini, E Anzon, G Pogliaghi, L Radice, A Bernelli‐Zazzera – 1 July 1996 – The expression of hsp70–the inducible member of the corresponding heat shock gene family‐of the oxidative stress marker gene heme oxygenase (HOx), and of the immediate early response genes c‐fos and c‐jun has been studied in FAO hepatocarcinoma cells depleted of polyamines and exposed to heat shock.

D Fukumura, Y Yonei, I Kurose, H Saito, T Ohishi, H Higuchi, S Miura, S Kato, H Kimura, H Ebinuma, H Ishi – 1 July 1996 – The metabolic change in tumor cells (AH70, a rat hepatoma cell line) cocultured with isolated rat Kupffer cells were visualized and analyzed by a laser scanning confocal imaging system. When AH70 cells were cocultured with Kupffer cells, fluorescence intensity of rhodamine 123 (Rh123) decreased, indicating the reduction of mitochondrial function.

A D'Errico, M Fiorentino, A Ponzetto, Y Daikuhara, H Tsubouchi, C Brechot, J Scoazec, W F Grigioni – 1 July 1996 – Increased levels of expression of hepatocyte growth factor (HGF) and its specific receptor c‐met have been shown in the liver of several benign and malignant pathologies, both in experimental models and humans. We investigated by immunohistochemistry the presence of both HGF and c‐met protoocogene product (c‐met pp) in 20 hepatocellular carcinomas (HCCs), 5 focal nodular hyperplasias (FNHs), 4 cases of fulminant hepatitis (FH), and 1 case of regenerated liver.