Natural history of nonalcoholic fatty liver disease: A prospective follow‐up study with serial biopsies

Patrik Nasr, Simone Ignatova, Stergios Kechagias, Mattias Ekstedt – 27 December 2017 – Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in the world. The complete natural history of NAFLD is unknown because few high‐quality follow‐up studies have been conducted. Our aim was to find variables predicting disease severity through an extended follow‐up with serial biopsies.

Normothermic machine perfusion of donor livers without the need for human blood products

Alix P. M. Matton, Laura C. Burlage, Rianne van Rijn, Yvonne de Vries, Shanice A. Karangwa, Maarten W. Nijsten, Annette S. H. Gouw, Janneke Wiersema‐Buist, Jelle Adelmeijer, Andrie C. Westerkamp, Ton Lisman, Robert J. Porte – 27 December 2017 – Normothermic machine perfusion (NMP) enables viability assessment of donor livers prior to transplantation. NMP is frequently performed by using human blood products including red blood cells (RBCs) and fresh frozen plasma (FFP).

Macrotrabecular‐massive hepatocellular carcinoma: A distinctive histological subtype with clinical relevance

Marianne Ziol, Nicolas Poté, Giuliana Amaddeo, Alexis Laurent, Jean‐Charles Nault, Frédéric Oberti, Charlotte Costentin, Sophie Michalak, Mohamed Bouattour, Claire Francoz, Georges Philippe Pageaux, Jeanne Ramos, Thomas Decaens, Alain Luciani, Boris Guiu, Valérie Vilgrain, Christophe Aubé, Jonathan Derman, Cécile Charpy, Jessica Zucman‐Rossi, Nathalie Barget, Olivier Seror, Nathalie Ganne‐Carrié, Valérie Paradis, Julien Calderaro – 27 December 2017 – We recently identified a histological subtype of hepatocellular carcinoma (HCC), designated as “macrotrabecular‐massive” (MTM‐HCC) and associa

Natural history of nonalcoholic fatty liver disease: A prospective follow‐up study with serial biopsies

Patrik Nasr, Simone Ignatova, Stergios Kechagias, Mattias Ekstedt – 27 December 2017 – Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in the world. The complete natural history of NAFLD is unknown because few high‐quality follow‐up studies have been conducted. Our aim was to find variables predicting disease severity through an extended follow‐up with serial biopsies.

Impact of abdominal shape on living liver donor outcomes in mini‐incision right hepatic lobectomy: Comparison among 3 techniques

Mohamed Safwan, Shunji Nagai, Kelly Collins, Michael Rizzari, Atsushi Yoshida, Marwan Abouljoud – 27 December 2017 – Although minimally invasive techniques for living donor hepatectomy have been developed, the surgical feasibility and limitations remain to be elucidated. The risks and outcomes involved need to be better understood prior to their widespread application. The aim of this study was to assess feasibility of minimally invasive donor hepatectomy by reviewing our experience.

Drug idiosyncrasy due to pirfenidone presenting as acute liver failure: Case report and mini‐review of the literature

Nipun Verma, Pramod Kumar, Suvradeep Mitra, Sunil Taneja, Sahajal Dhooria, Ashim Das, Ajay Duseja, Radha Krishan Dhiman, Yogesh Chawla – 27 December 2017 – Idiosyncratic drug‐induced liver injury (DILI) is ranked among the top most common etiologies of acute liver failure (ALF). It carries poor transplant‐free survival. Pirfenidone is an anti‐inflammatory and antifibrotic drug that is commonly used for the treatment of idiopathic pulmonary fibrosis (IPF). Hepatotoxicity due to pirfenidone is rare and generally manifests as a mild rise in serum aminotransferases.

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