Notices
17 January 2018
Hepatology Highlights
Nicholas Russo, Robert S. Brown, Russell Rosenblatt, Robert E. Schwartz, Shawn Shah, Clara Tow, Nicole T. Shen, Saurabh Mukewar, Vikas Gupta, Aleksey Novikov – 17 January 2018
Cover Image
17 January 2018
A new mechanism of action of glucagon‐like peptide‐1 agonist in hepatic steatosis: Promotion of hepatic insulin clearance through induction of carcinoembryonic antigen‐related cell adhesion molecule 1
Torrey Y. Czech, Qinglan Wang, Ekihiro Seki – 16 January 2018
Lean NAFLD: A not so benign condition?
Lisa B. VanWagner, Matthew J. Armstrong – 16 January 2018
Issue Information
16 January 2018
A fixed partial epithelial‐mesenchymal transition (EMT) triggers carcinogenesis, whereas asymmetrical division of hybrid EMT cells drives cancer progression
Evgeny V. Denisov, Vladimir M. Perelmuter – 13 January 2018
Primary biliary cholangitis, DNA, and beyond: The Relative contribution of genes
Aliya F. Gulamhusein, Konstantinos N. Lazaridis – 13 January 2018
Hepatic PPARα function is controlled by polyubiquitination and proteasome‐mediated degradation through the coordinated actions of PAQR3 and HUWE1
Zilong Zhao, Daqian Xu, Zheng Wang, Lin Wang, Ruomei Han, Zhenzhen Wang, Lujian Liao, Yan Chen – 13 January 2018 – Peroxisome proliferator‐activated receptor α (PPARα) is a key transcriptional factor that regulates hepatic lipid catabolism by stimulating fatty acid oxidation and ketogenesis in an adaptive response to nutrient starvation. However, how PPARα is regulated by posttranslational modification is poorly understood.
Cellular Membrane Trafficking Machineries Used by the Hepatitis Viruses
Jun Inoue, Masashi Ninomiya, Tooru Shimosegawa, Mark A. McNiven – 13 January 2018 – While the life cycles of hepatitis viruses (A, B, C, D, and E) have been modestly characterized, recent intensive studies have provided new insights. Because these viruses “hijack” the membrane trafficking of the host cell machinery during replicative propagation, it is essential to determine and understand these specific cellular pathways. Hepatitis B virus (HBV) and hepatitis C virus are well known as leading causes of liver cirrhosis and hepatocellular carcinoma.