Robert Holz, Andreas E. Kremer, Dieter Lütjohann, Hermann E. Wasmuth, Frank Lammert, Marcin Krawczyk – 10 January 2018 – Benign recurrent intrahepatic cholestasis (BRIC) is a peculiar familial disease caused by mutations of the genes encoding hepatocanalicular flippase for phosphatidylserine (ATP8B1; BRIC type 1) or the bile salt export pump (ABCB11; BRIC type 2). Here, we report on a patient with nasobiliary drainage‐refractory BRIC type 2 who improved under plasma separation and anion absorption therapy.

Yuli Cai, Honggui Li, Mengyang Liu, Ya Pei, Juan Zheng, Jing Zhou, Xianjun Luo, Wenya Huang, Linqiang Ma, Qiuhua Yang, Shaodong Guo, Xiaoqiu Xiao, Qifu Li, Tianshu Zeng, Fanyin Meng, Heather Francis, Shannon Glaser, Lulu Chen, Yuqing Huo, Gianfranco Alpini, Chaodong Wu – 9 January 2018 – Adenosine 2A receptor (A2AR) exerts protective roles in endotoxin‐ and/or ischemia‐induced tissue damage. However, the role for A2AR in nonalcoholic fatty liver disease (NAFLD) remains largely unknown.

Ruben Hernaez, Fasiha Kanwal, Hashem B. El‐Serag – 9 January 2018

Katherine Arndtz, Gideon M. Hirschfield – 9 January 2018

Hongping Zheng, Yotsawat Pomyen, Maria Olga Hernandez, Caiyi Li, Ferenc Livak, Wei Tang, Hien Dang, Tim F. Greten, Jeremy L. Davis, Yongmei Zhao, Monika Mehta, Yelena Levin, Jyoti Shetty, Bao Tran, Anuradha Budhu, Xin Wei Wang – 9 January 2018 – Intratumor molecular heterogeneity of hepatocellular carcinoma is partly attributed to the presence of hepatic cancer stem cells (CSCs). Different CSC populations defined by various cell surface markers may contain different oncogenic drivers, posing a challenge in defining molecularly targeted therapeutics.

Andrew Wey, Joshua Pyke, David P. Schladt, Sommer E. Gentry, Tim Weaver, Nicholas Salkowski, Bertram L. Kasiske, Ajay K. Israni, Jon J. Snyder – 9 January 2018 – Offer acceptance practices may cause geographic variability in allocation Model for End‐Stage Liver Disease (aMELD) score at transplant and could magnify the effect of donor supply and demand on aMELD variability.

Jacqueline G. O'Leary, K. Rajender Reddy, Guadalupe Garcia‐Tsao, Scott W. Biggins, Florence Wong, Michael B. Fallon, Ram M. Subramanian, Patrick S. Kamath, Paul Thuluvath, Hugo E. Vargas, Benedict Maliakkal, Puneeta Tandon, Jennifer Lai, Leroy R. Thacker, Jasmohan S. Bajaj – 8 January 2018 – The North American Consortium for the Study of End‐Stage Liver Disease's definition of acute‐on‐chronic liver failure (NACSELD‐ACLF) as two or more extrahepatic organ failures has been proposed as a simple bedside tool to assess the risk of mortality in hospitalized patients with cirrhosis.

Kavish R. Patidar, Le Kang, Jasmohan S. Bajaj, Daniel Carl, Arun J. Sanyal – 8 January 2018 – Current approaches to determine the cause of acute kidney injury (AKI) in patients with cirrhosis are suboptimal. The aim of this study was to determine the utility of fractional excretion of urea (FEUrea) for the differential diagnosis of AKI in patients with cirrhosis. A retrospective analysis was performed in patients (n = 50) with cirrhosis and ascites admitted with AKI.

Leonard Knegendorf, Svenja A. Drave, Viet Loan Dao Thi, Yannick Debing, Richard J. P. Brown, Florian W. R. Vondran, Kathrin Resner, Martina Friesland, Tanvi Khera, Michael Engelmann, Birgit Bremer, Heiner Wedemeyer, Patrick Behrendt, Johan Neyts, Thomas Pietschmann, Daniel Todt, Eike Steinmann – 8 January 2018 – Hepatitis E virus (HEV) is a member of the genus Orthohepevirus in the family Hepeviridae and the causative agent of hepatitis E in humans. HEV is a major health problem in developing countries, causing mortality rates up to 25% in pregnant women.

Sanchuan Lai, Yasuko Iwakiri – 8 January 2018