Diet affects gut microbiota and modulates hospitalization risk differentially in an international cirrhosis cohort

Jasmohan S. Bajaj, Ramazan Idilman, Leila Mabudian, Matthew Hood, Andrew Fagan, Dilara Turan, Melanie B. White, Fatih Karakaya, Jessica Wang, Rengül Atalay, Phillip B. Hylemon, Edith A. Gavis, Robert Brown, Leroy R. Thacker, Chathur Acharya, Douglas M. Heuman, Masoumeh Sikaroodi, Patrick M. Gillevet – 19 January 2018 – The relative ranking of cirrhosis‐related deaths differs between high‐/middle‐income countries. Gut microbiome is affected in cirrhosis and is related to diet. Our aim was to determine the effect of differing dietary habits on gut microbiota and clinical outcomes.

Randomized trial on extended versus modified right lobe grafts in living donor liver transplantation

Christi Titus Varghese, Viju Kumar Bharathan, Unnikrishnan Gopalakrishnan, Dinesh Balakrishnan, Ramachandran N. Menon, Othiyil Vayoth Sudheer, Puneet Dhar, Surendran Sudhindran – 19 January 2018 – Despite advances in the practice of living donor liver transplantation (LDLT), the optimum surgical approach with respect to the middle hepatic vein (MHV) in right lobe LDLT remains undefined.

Heparin but not tissue plasminogen activator improves outcomes in donation after circulatory death liver transplantation in a porcine model

Amelia J. Hessheimer, Marina Vendrell, Javier Muñoz, Ángel Ruíz, Alba Díaz, Luís Flores Sigüenza, Jorge Rodríguez Lanzilotta, Eduardo Delgado Oliver, Jose Fuster, Miquel Navasa, Juan Carlos García‐Valdecasas, Pilar Taurá, Constantino Fondevila – 19 January 2018 – Ischemic‐type biliary lesions (ITBLs) arise most frequently after donation after circulatory death (DCD) liver transplantation and result in high morbidity and graft loss. Many DCD grafts are discarded out of fear for this complication.

Hepatitis B virus surface gene pre‐S2 mutant as a high‐risk serum marker for hepatoma recurrence after curative hepatic resection

Chia‐Jui Yen, Yu‐Lin Ai, Hung‐Wen Tsai, Shih‐Huang Chan, Chia‐Sheng Yen, Kuang‐Hsiung Cheng, Yun‐Ping Lee, Chia‐Wei Kao, Yu‐Chun Wang, Yi‐Lin Chen, Cheng‐Han Lin, Tsunglin Liu, Huey‐Pin Tsai, Jen‐Ren Wang, Ih‐Jen Su, Wenya Huang – 19 January 2018 – Chronic hepatitis B virus (HBV) infection is the major cause of hepatocellular carcinoma (HCC). The pre‐S2 mutant large HBV surface antigen (LHBS) is highly associated with HCC.

Acute decompensation boosts hepatic collagen type III deposition and deteriorates experimental and human cirrhosis

Michael Praktiknjo, Jennifer Lehmann, Mette J. Nielsen, Robert Schierwagen, Frank E. Uschner, Carsten Meyer, Daniel Thomas, Christian P. Strassburg, Flemming Bendtsen, Søren Møller, Aleksander Krag, Morten A. Karsdal, Diana J. Leeming, Jonel Trebicka – 18 January 2018 – Patients with end‐stage liver disease develop acute decompensation (AD) episodes, which become more frequent and might develop into acute‐on‐chronic liver failure (ACLF). However, it remains unknown how AD induces acceleration of liver disease.

Incidence and cost analysis of hospital admission and 30‐day readmission among patients with cirrhosis

Sakkarin Chirapongsathorn, Chayakrit Krittanawong, Felicity T. Enders, Richard Pendegraft, Kristin C. Mara, Bijan J. Borah, Sue L. Visscher, Conor G. Loftus, Vijay H. Shah, Jayant A. Talwalkar, Patrick S. Kamath – 18 January 2018 – We examined risks for first hospitalization and the rate, risk factors, costs, and 1‐year outcome of 30‐day readmission among patients admitted for complications of cirrhosis.

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