The Wnt/β‐catenin pathway determines the predisposition and efficiency of liver‐to‐pancreas reprogramming

Helit Cohen, Hila Barash, Irit Meivar‐Levy, Kfir Molakandov, Marina Ben‐Shimon, Michael Gurevich, Fatima Zoabi, Adi Har‐Zahav, Rolf Gebhardt, Frank Gaunitz, Michael Gurevich, Eytan Mor, Philippe Ravassard, Shoshana Greenberger, Sarah Ferber – 2 February 2018 – Transdifferentiation (TD) is the direct reprogramming of adult cells into cells of alternate fate and function. We have previously shown that liver cells can be transdifferentiated into beta‐like, insulin‐producing cells through ectopic expression of pancreatic transcription factors (pTFs).

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Qiang Liu, Laura Buccini, Daniele Pezzati, Ahmed Hassan, Teresa Diago Uso, Charles Miller, Cristiano Quintini – 1 February 2018

Role of monocyte chemoattractant protein‐1 in liver fibrosis with transient myeloproliferative disorder in down syndrome

Kenichiro Kobayashi, Takako Yoshioka, Jun Miyauchi, Atsuko Nakazawa, Nobutaka Kiyokawa, Toshiro Maihara, Ikuya Usami – 1 February 2018 – Liver fibrosis is a common complication associated with transient myeloproliferative disorder (TMD) in Down syndrome (DS). The exact molecular pathogenesis that regulates disease progression is largely unknown. We recently found serum and/or urinary monocyte chemoattractant protein‐1 (MCP‐1) as a novel biomarker of liver fibrosis.

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