Great Expectations: Principal Investigator and Trainee Perspectives on Hiring, Supervision, and Mentoring
Leonard Kaps, Jonathan G. Stine, Jessica Mellinger, Silvia Vilarinho – 7 September 2018 – A functioning mentor–trainee relationship is of high importance in academia. Discrepancies in expectations between principal investigators (PIs) and trainees are a source of misunderstandings and conflicts, endangering scientific progress and career advancement.
Aortic Versus Dual Perfusion for Retrieval of the Liver After Brain Death: A National Registry Analysis
Ahmer M. Hameed, Tony Pang, Peter Yoon, Glenda Balderson, Ronald De Roo, Lawrence Yuen, Vincent Lam, Jerome Laurence, Michael Crawford, Richard D. M. Allen, Wayne J. Hawthorne, Henry C. Pleass – 7 September 2018 – There is lack of consensus in the literature regarding the comparative efficacy of in situ aortic‐only compared with dual (aortic and portal venous) perfusion for retrieval and transplantation of the liver.
The Association Between Nonalcoholic Fatty Liver Disease and Cardiovascular Disease Outcomes
Carrie R. Wong, Joseph K. Lim – 7 September 2018
Viability Criteria for Functional Assessment of Donor Livers During Normothermic Machine Perfusion
Otto B. van Leeuwen, Vincent E. de Meijer, Robert J. Porte – 7 September 2018
Closing the Quality Chasm in Cirrhosis
Kai Rou Tey, Prashanthinie Mohan, Xibei Liu, Archita P. Desai – 7 September 2018
Follicular T Helper Cell Signatures in Primary Biliary Cholangitis and Primary Sclerosing Cholangitis
Leonie Adam, Katharina Zoldan, Maike Hofmann, Michael Schultheiss, Dominik Bettinger, Christoph Neumann‐Haefelin, Robert Thimme, Tobias Boettler – 7 September 2018 – Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are the most common cholestatic liver diseases. While PBC is generally accepted to be an autoimmune disorder characterized by pathognomonic autoantibodies against mitochondrial antigens, the pathogenesis of PSC is less precisely defined; however, some degree of altered immunity toward autoantigens has been suggested.
Liver Disease in Cystic Fibrosis: Illuminating the Black Box
Carla Colombo, Gianfranco Alicandro – 6 September 2018
A Rare Nonsense Mutation in the Glucokinase Regulator Gene Is Associated With a Rapidly Progressive Clinical Form of Nonalcoholic Steatohepatitis
Carlos J. Pirola, Diego Flichman, Hernán Dopazo, Tomas Fernández Gianotti, Julio San Martino, Cristian Rohr, Martin Garaycoechea, Carla Gazzi, Gustavo O. Castaño, Silvia Sookoian – 5 September 2018 – We report on the presence of a rare nonsense mutation (rs149847328, p.Arg227Ter) in the glucokinase regulator (GCKR) gene in an adult patient with nonalcoholic fatty liver disease (NAFLD), morbid obesity, and type 2 diabetes; this patient developed a progressive histological form of the disease.
Whole‐Exome Sequencing Study of Extreme Phenotypes of NAFLD
Sarah E. Kleinstein, Matthew Rein, Manal F. Abdelmalek, Cynthia D. Guy, David B. Goldstein, Anna Mae Diehl, Cynthia A. Moylan – 5 September 2018 – Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous disease with highly variable outcomes. Patients with simple steatosis typically experience a benign course, whereas those with more advanced liver injury, nonalcoholic steatohepatitis (NASH), and advanced stage fibrosis suffer increased risk for complications such as cirrhosis, hepatic decompensation, and liver cancer.