Direct‐acting antivirals do not increase the risk of hepatocellular carcinoma recurrence after local‐regional therapy or liver transplant waitlist dropout

Annsa C. Huang, Neil Mehta, Jennifer L. Dodge, Francis Y. Yao, Norah A. Terrault – 24 February 2018 – Whether direct‐acting antivirals (DAAs) increase the risk of hepatocellular carcinoma (HCC) recurrence after tumor‐directed therapy is controversial. We sought to determine the impact of DAA therapy on HCC recurrence after local‐regional therapy (LRT) and waitlist dropout among liver transplant (LT) candidates with HCC. We performed a retrospective cohort study of 149 LT candidates with hepatitis C virus (HCV) and HCC at a single center from 2014 through 2016.

Fibroblast growth factor 21 is an early predictor of acute‐on‐chronic liver failure in critically ill patients with cirrhosis

Astrid Ruiz‐Margáin, Alessandra Pohlmann, Patrick Ryan, Robert Schierwagen, Luis A. Chi‐Cervera, Christian Jansen, Osvely Mendez‐Guerrero, Nayelli C. Flores‐García, Jennifer Lehmann, Aldo Torre, Ricardo Ulises Macías‐Rodríguez, Jonel Trebicka – 24 February 2018 – Acute‐on‐chronic liver failure (ACLF) develops in acute decompensation (AD) of cirrhosis and shows high mortality. In critically ill patients, early diagnosis of ACLF could be important for therapeutic decisions (eg, renal replacement, artificial liver support, liver transplantation).

Impact of a first study of early transplantation in acute alcoholic hepatitis: Results of a nationwide survey in french liver transplantation programs

Teresa Maria Antonini, Olivier Guillaud, Jérôme Dumortier, Sébastien Dharancy, Faouzi Saliba, Philippe Mathurin, Jean‐Charles Duclos‐Vallée, Christophe Duvoux, for Groupe de Recherche Français en Greffe de Foie (GReF2) – 24 February 2018

Elbasvir/grazoprevir and sofosbuvir for hepatitis C virus genotype 3 infection with compensated cirrhosis: A randomized trial

Graham R. Foster, Kosh Agarwal, Matthew E. Cramp, Sulleman Moreea, Stephen Barclay, Jane Collier, Ashley S. Brown, Stephen D. Ryder, Andrew Ustianowski, Daniel M. Forton, Ray Fox, Fiona Gordon, William M. Rosenberg, David J. Mutimer, Jiejun Du, Christopher L. Gilbert, Ernest Asante‐Appiah, Janice Wahl, Michael N. Robertson, Eliav Barr, Barbara Haber – 23 February 2018 – Many direct‐acting antiviral regimens have reduced activity in people with hepatitis C virus (HCV) genotype (GT) 3 infection and cirrhosis.

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