Xiao‐Jing Zhang, Zhi‐Gang She, Hongliang Li – 16 February 2018

Quirino Lai, Alessandro Vitale – 16 February 2018

Ka Wing Ma, Kenneth Siu Ho Chok, Wong Hoi She, Albert Chi Yan Chan, Tan To Cheung, Wing Chiu Dai, James Yan Yue Fung, Chung Mau Lo – 16 February 2018 – Salvage liver transplantation (sLT) and repeated resection (RR) are effective treatments for recurrent hepatocellular carcinoma (HCC), and comparisons of the oncological outcomes between these 2 modalities were scarce. Consecutive patients admitted for either sLT or RR for recurrent HCC were recruited. All patients in the present series received either prior hepatectomy, ablative therapy, or both before RR or sLT.

Acute on chronic liver failure is increasingly understood in adults, less so in children. The aims of this Webinar are to increase understanding about the causes of acute liver decompensation in children with chronic, compensated liver disease, and the acute-care management of ACLF.John Bucuvalas (Moderator) John Bucuvalas MD, FAASLD is Professor of Pediatrics and has a broad background in transplant hepatology.

Wei Zhu, Yibing Peng, Lan Wang, Yuan Hong, Xiaotao Jiang, Qi Li, Heping Liu, Lei Huang, Juan Wu, Esteban Celis, Todd Merchen, Edward Kruse, Yukai He – 14 February 2018 – Hepatocellular carcinoma (HCC) is the major form of liver cancer for which there is no effective therapy. Genetic modification with T‐cell receptors (TCRs) specific for HCC‐associated antigens, such as α‐fetoprotein (AFP), can potentially redirect human T cells to specifically recognize and kill HCC tumor cells to achieve antitumor effects.

Naga Chalasani, on behalf of the Writing Group for the AASLD NAFLD Practice Gudiance – 14 February 2018

William Carey – 14 February 2018

Johnny Amer, Ahmad Salhab, Mazen Noureddin, Sarit Doron, Lina Abu‐Tair, Rami Ghantous, Mahmud Mahamid, Rifaat Safadi – 14 February 2018 – Insulin resistance is a key risk factor in the progression of nonalcoholic fatty liver disease (NAFLD) and may lead to liver fibrosis. Natural killer (NK) cells are thought to exert an antifibrotic effect through their killing of activated hepatic stellate cells (HSCs). Here, we investigated how the interplay between NK cells and HSCs are modified by insulin resistance in NAFLD.

Young‐Chan Kwon, Keith Meyer, Guangyong Peng, Soumya Chatterjee, Daniel F. Hoft, Ranjit Ray – 14 February 2018 – A comprehensive strategy to control hepatitis C virus (HCV) infection needs a vaccine. Our phase I study with recombinant HCV E1/E2 envelope glycoprotein (EnvGPs) as a candidate vaccine did not induce a strong immune response in volunteers. We analyzed the interactions of HCV EnvGPs with human monocyte‐derived macrophages as antigen‐presenting cells.

Yosuke Osawa, Ekumi Kojika, Yukiko Hayashi, Masamichi Kimura, Koji Nishikawa, Sachiyo Yoshio, Hiroyoshi Doi, Tatsuya Kanto, Kiminori Kimura – 13 February 2018 – Hepatocyte apoptosis has been implicated in the progression of nonalcoholic steatohepatitis. However, it is unclear whether the induction of tumor necrosis factor (TNF)‐α‐mediated hepatocyte apoptosis in the simple fatty liver triggers liver fibrosis. To address this question, high‐fat diet‐fed mice were repeatedly administered D‐galactosamine, which increases the sensitivity of hepatocytes to TNF‐α‐mediated apoptosis.