Use of the CRISPR/Cas9‐based epigenetic gene activation system In Vivo: A new potential therapeutic modality
Samar H. Ibrahim, Keith D. Robertson – 28 February 2018
Pro: Moderate alcohol use is beneficial in nonalcoholic steatohepatitis
Scott McHenry, Saad Alghamdi, Mauricio Lisker‐Melman – 28 February 2018
Think global, act local: Responsibility for the liver transplant candidate
Peter L. Abt, Kim M. Olthoff – 28 February 2018
Clinical Liver Disease: Introducing hot topics in hepatology
Lisa B. VanWagner, Nancy Reau – 28 February 2018
Hepatic diagnostics in pregnancy: Biopsy, biomarkers, and beyond
Michael A. Heneghan, Mary D. Cannon – 27 February 2018
Daclatasvir and sofosbuvir treatment of decompensated liver disease or post‐liver transplant hepatitis C virus recurrence in patients with advanced liver disease/cirrhosis in a real‐world cohort
Paul Kwo, Michael W. Fried, K. Rajender Reddy, Consuelo Soldevila‐Pico, Saro Khemichian, Jama Darling, Phillippe J. Zamor, Andrew A. Napoli, Beatrice Anduze‐Faris, Robert S. Brown – 27 February 2018 – We report the findings of an early access program providing treatment for chronic hepatitis C virus infection (any genotype) with daclatasvir and sofosbuvir with/without ribavirin to patients with Child‐Pugh class C cirrhosis or prior liver transplant recipients with recurrent hepatitis C virus infection and advanced fibrosis/cirrhosis.
Glycogen storage disease type Ia: Adult presentation with microcytic anemia and liver adenomas
Wouter Moest, Wendy van der Deure, Ted Koster, Marcela Spee‐Dropková, Linda Swart‐Busscher, Robbert J. de Haas, Terry G.J. Derks – 27 February 2018
Intestine farnesoid X receptor agonist and the gut microbiota activate G‐protein bile acid receptor‐1 signaling to improve metabolism
Preeti Pathak, Cen Xie, Robert G. Nichols, Jessica M. Ferrell, Shannon Boehme, Kristopher W. Krausz, Andrew D. Patterson, Frank J. Gonzalez, John Y.L. Chiang – 27 February 2018 – Bile acids activate farnesoid X receptor (FXR) and G protein–coupled bile acid receptor‐1 (aka Takeda G protein–coupled receptor‐5 [TGR5]) to regulate bile acid metabolism and glucose and insulin sensitivity. FXR and TGR5 are coexpressed in the enteroendocrine L cells, but their roles in integrated regulation of metabolism are not completely understood.
Transient elastography is useful in diagnosing biliary atresia and predicting prognosis after hepatoportoenterostomy
Jia‐Feng Wu, Chee‐Seng Lee, Wen‐Hsi Lin, Yung‐Ming Jeng, Huey‐Ling Chen, Yen‐Hsuan Ni, Hong‐Yuan Hsu, Mei‐Hwei Chang – 27 February 2018 – We investigated the utility of transient elastography (TE) for diagnosing biliary atresia (BA) in cholestatic infants and predicting the outcome of BA. Forty‐eight cholestatic infants (9‐87 days of age) with direct bilirubin level >1 mg/dL were enrolled. Liver stiffness measurement (LSM) by TE was performed during the cholestasis workup, and 15 subjects were diagnosed as BA.
Glycogen storage disease type Ia: Adult presentation with microcytic anemia and liver adenomas
Wouter Moest, Wendy van der Deure, Ted Koster, Marcela Spee‐Dropková, Linda Swart‐Busscher, Robbert J. de Haas, Terry G.J. Derks – 27 February 2018