Fluorescent peptide highlights micronodules in murine hepatocellular carcinoma models and humans in vitro

Renwei Jing, Xiaoli Zhou, Jingwen Zhao, Yushuang Wei, Bingfeng Zuo, Abin You, Quan Rao, Xianjun Gao, Rong Yang, Lu Chen, Zhen Lu, Qibing Zhou, Ning Zhang, HaiFang Yin – 5 February 2018 – Early detection and clear delineation of microscopic lesions during surgery are critical to the prognosis and survival of patients with hepatocellular carcinoma (HCC), a devastating malignancy without effective treatments except for resection. Tools to specifically identify and differentiate micronodules from normal tissue in HCC patients can have a positive impact on survival.

The Wnt/β‐catenin pathway determines the predisposition and efficiency of liver‐to‐pancreas reprogramming

Helit Cohen, Hila Barash, Irit Meivar‐Levy, Kfir Molakandov, Marina Ben‐Shimon, Michael Gurevich, Fatima Zoabi, Adi Har‐Zahav, Rolf Gebhardt, Frank Gaunitz, Michael Gurevich, Eytan Mor, Philippe Ravassard, Shoshana Greenberger, Sarah Ferber – 2 February 2018 – Transdifferentiation (TD) is the direct reprogramming of adult cells into cells of alternate fate and function. We have previously shown that liver cells can be transdifferentiated into beta‐like, insulin‐producing cells through ectopic expression of pancreatic transcription factors (pTFs).

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