Endoplasmic Reticulum Stress Causes Liver Cancer Cells to Release Exosomal miR‐23a‐3p and Up‐regulate Programmed Death Ligand 1 Expression in Macrophages

Jiatao Liu, Lulu Fan, Hanqing Yu, Ju Zhang, Yong He, Dechun Feng, Fang Wang, Xiaoqiu Li, Qingqing Liu, Yuhuan Li, Zhenli Guo, Bin Gao, Wei Wei, Hua Wang, Guoping Sun – 10 March 2019 – Endoplasmic reticulum (ER) stress promotes tumor cell escape from immunosurveillance. However, the underlying mechanisms remain unknown. We hypothesized that ER stress induces hepatocellular carcinoma (HCC) cells to release exosomes, which attenuate antitumor immunity by modulating the expression of programmed death ligand 1 (PD‐L1) in macrophages.

Metabolism‐induced tumor activator 1 (MITA1), an Energy Stress–Inducible Long Noncoding RNA, Promotes Hepatocellular Carcinoma Metastasis

Meilin Ma, Haixia Xu, Geng Liu, Jing Wu, Chunhua Li, Xiuxuan Wang, Sifan Zhang, Heng Xu, Shenggen Ju, Wei Cheng, Lunzhi Dai, Yuquan Wei, Yan Tian, Xianghui Fu – 6 March 2019 – Metastasis is the main cause of cancer‐related death, yet the underlying mechanisms are still poorly understood. Long noncoding RNAs (lncRNAs) are emerging as crucial regulators of malignancies; however, their functions in tumor metastasis remain largely unexplored.

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Kristina Behnke, Yuan Zhuang, Haifeng C. Xu, Balamurugan Sundaram, Maria Reich, Prashant V. Shinde, Jun Huang, Nastaran Fazel Modares, Alexei V. Tumanov, Robin Polz, Jürgen Scheller, Carl F. Ware, Klaus Pfeffer, Verena Keitel, Dieter Häussinger, Aleksandra A. Pandyra, Karl S. Lang, Philipp A. Lang – 4 March 2019

When the Creation of a Consortium Provides Useful Answers: Experience of The Latin American DILI Network (LATINDILIN)

Fernando Bessone, Nelia Hernandez, Manuel Mendizabal, Adriana Sanchez, Raymundo Paraná, Marco Arrese, Martin Tagle, Marcos Girala, Maribel Lizarzabal, Enrique Carrera, Javier Brahm, Fernando Contreras, Nahum Mendez‐Sanchez, Genario Santos, Vinicius Nunes, Inmaculada Medina‐Caliz, Cecilio Parra‐Martinez, Laura Sanz‐Villanueva, Maria Isabel Lucena, Raul J. Andrade – 4 March 2019

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