Hepatology Highlights

Kavitha M. Nair, Ravi S. Vora, Omar Y Mousa, Harmeet Malhi, Robert E. Schwartz, Joseph F. Pisa, Robert S. Brown, Hirsh D. Trivedi, Daryl T.Y. Lau, Nicole Shen, Akhil Shenoy, Jessica L. Maiers, Enis Kostallari, Petra Hirsova, Nicholas Russo, Tasha B. Kulai – 28 March 2019

Clinical Implications of Donor Warm and Cold Ischemia Time in Donor After Circulatory Death Liver Transplantation

Flavio Paterno, James V. Guarrera, Koffi Wima, Tayyab Diwan, Madison C. Cuffy, Nadeem Anwar, E. Steve Woodle, Shimul Shah – 26 March 2019 – The use of donation after circulatory death (DCD) liver allografts has been constrained by limitations in the duration of donor warm ischemia time (DWIT), donor agonal time (DAT), and cold ischemia time (CIT). The purpose of this study is to assess the impact of longer DWIT, DAT, and CIT on graft survival and other outcomes in DCD liver transplants.

The Effects of Liver Transplantation in Children With Niemann‐Pick Disease Type B

Yuan Liu, Yi Luo, Lei Xia, Bijun Qiu, Tao Zhou, Mingxuan Feng, Feng Xue, Xiaosong Chen, Longzhi Han, Jianjun Zhang, Qiang Xia – 26 March 2019 – We evaluated the effects of liver transplantation (LT) in children with Niemann‐Pick disease (NPD) type B. From October 2006 to October 2018, 7 of 1512 children who received LT at Ren Ji Hospital were diagnosed as NPD type B. The median age at diagnosis was 12 months (6‐14 months) with initial presentations of hepatosplenomegaly, growth retardation, repeated pneumonia, and diarrhea.

Expanding and Underscoring the Hepato‐Encephalopathic Phenotype of QIL1/MIC13

Bianca E. Russell, Kaitlin G. Whaley, Kevin E. Bove, Anatalia Labilloy, Rachel C. Lombardo, Robert J. Hopkin, Nancy D. Leslie, Carlos Prada, Zahra Assouline, Giulia Barcia, Juliette Bouchereau, Maryline Chomton, Dominique Debray, Imen Dorboz, Philippe Durand, Pauline Gaignard, Dalila Habes, Claude Jardel, François Labarthe, Jonathan Lévy, Anne Lombès, Claire Mehler‐Jacob, Judith Melki, Laura Menvielle, Arnold Munnich, Charlotte Mussini, Samia Pichard, Marlène Rio, Agnès Rötig, Samira Sissaoui, Abdelhamid Slama, Alexander G Miethke, Manuel Schiff – 26 March 2019

Relationship Between PNPLA3 rs738409 Polymorphism and Decreased Kidney Function in Children With NAFLD

Giovanni Targher, Alessandro Mantovani, Anna Alisi, Antonella Mosca, Nadia Panera, Christopher D. Byrne, Valerio Nobili – 26 March 2019 – Emerging evidence suggests that patatin‐like phospholipase domain–containing protein‐3 (PNPLA3) rs738409 genotype (the major genetic variant associated with susceptibility to nonalcoholic fatty liver disease [NAFLD]) is associated with decreased kidney function in adults. Currently, it is uncertain whether this association also occurs in children/adolescents and whether any association is independent of liver disease severity.

Expanding and Underscoring the Hepato‐Encephalopathic Phenotype of QIL1/MIC13

Bianca E. Russell, Kaitlin G. Whaley, Kevin E. Bove, Anatalia Labilloy, Rachel C. Lombardo, Robert J. Hopkin, Nancy D. Leslie, Carlos Prada, Zahra Assouline, Giulia Barcia, Juliette Bouchereau, Maryline Chomton, Dominique Debray, Imen Dorboz, Philippe Durand, Pauline Gaignard, Dalila Habes, Claude Jardel, François Labarthe, Jonathan Lévy, Anne Lombès, Claire Mehler‐Jacob, Judith Melki, Laura Menvielle, Arnold Munnich, Charlotte Mussini, Samia Pichard, Marlène Rio, Agnès Rötig, Samira Sissaoui, Abdelhamid Slama, Alexander G Miethke, Manuel Schiff – 26 March 2019

Antegrade Hepatic Artery and Portal Vein Perfusion Versus Portal Vein Perfusion Alone in Living Donor Liver Transplantation: A Randomized Trial

Johns Shaji Mathew, K.Y. Santosh Kumar, Krishnanunni Nair, Binoj Sivasankara Pillai Thankamony Amma, Lakshmi Krishnakumar, Dinesh Balakrishnan, Unnikrishnan Gopalakrishnan, Ramachandran Narayana Menon, Aleena Sunny, Puneet Dhar, Sudheer Othiyil Vayoth, Sudhindran Surendran – 25 March 2019 – Traditionally, deceased donor liver grafts receive dual perfusion (DP) through the portal vein and the hepatic artery (HA) either in situ or on the back table. HA perfusion is avoided in living donor liver grafts for fear of damage to the intima and consequent risk of hepatic artery thrombosis (HAT).

Association Between Institutional Factors and Long‐Term Survival Following Transjugular Intrahepatic Portosystemic Shunt

Jeffrey M. Mah, Yvonne DeWit, Maya Djerboua, Alexandre Menard, Christopher M. Booth, Jennifer A. Flemming – 25 March 2019 – Transjugular intrahepatic portosystemic shunt (TIPS) is a procedure designed to treat portal hypertension. Hospital teaching status is an institutional factor found to be predictive of outcomes following several complex procedures; however, its impact on outcomes following TIPS is unknown. The aim of this study was to determine the association between hospital teaching status and long‐term survival in patients with cirrhosis receiving TIPS.

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