Keiichi Fujiwara, Masayuki Nakano, Shin Yasui, Osamu Yokosuka, Naoya Kato – 22 March 2019

Mussarat N. Rahim, Rodrigo Liberal, Rosa Miquel, Nigel D. Heaton, Michael A. Heneghan – 22 March 2019 – Acute severe presentations of autoimmune hepatitis (AIH) represent a challenge for the transplant community. As a disease, it is poorly characterized, and there is a weak evidence base to guide diagnosis and treatment. Early identification of acute severe AIH is key because it determines the initiation of corticosteroids, which can be lifesaving. However, their use in this setting remains controversial.

Banishree Saha, David Tornai, Karen Kodys, Adeyinka Adejumo, Patrick Lowe, Craig McClain, Mack Mitchell, Arthur McCullough, Srinivasan Dasarathy, Aimee Kroll‐Desrosiers, Bruce Barton, Svetlana Radaeva, Gyongyi Szabo – 19 March 2019 – Although mortality due to acute alcoholic hepatitis (AH) correlates with Model for End‐Stage Liver Disease (MELD) scores, biomarkers are critically needed to manage this disease. Increases in inflammatory markers and macrophage activation are associated with acute AH and could be potential biomarkers of clinical events and/or mortality.

Felix Piecha, Jan‐Michael Gänßler, Sabine Jordan, Can Ergen, Harald Ittrich, Johannes Kluwe, Sven Pischke, Ansgar W. Lohse, Julian Schulze zur Wiesch – 18 March 2019 – Direct‐acting antiviral (DAA) therapies have revolutionized the treatment of chronic hepatitis C virus infection, achieving sustained virological response (SVR) rates of >90% even in patients with advanced liver cirrhosis.

Narendra S. Choudhary, Sanjiv Saigal, Neeraj Saraf, Arvinder S. Soin – 18 March 2019

Jian He, Ai‐Min Leng – 18 March 2019

Connie W. Wang, Adrienne Lebsack, Stephanie Chau, Jennifer C. Lai – 18 March 2019 – The Liver Frailty Index (LFI), composed of 3 performance‐based tests (grip strength, chair stands, and balance), is a tool specifically developed in patients with cirrhosis to objectively measure physical function, a critical determinant of health outcomes.

Damiano Patrono, Eloisa Franchi, Fabio Guarasci, Germana Bartoli, Elisabetta Nada, Federica Rigo, Antonio Ottobrelli, Paolo Fonio, Mauro Salizzoni, Renato Romagnoli – 18 March 2019 – Splenic artery (SA) ligation can be performed during liver transplantation (LT) to avoid portal hyperperfusion, which is involved in the pathogenesis of both small‐for‐size and SA syndrome. The SA can also be used as an inflow for arterial reconstruction.

Brian P. Lee, Gene Y. Im, John P. Rice, Ethan Weinberg, Christine Hsu, Oren K. Fix, George Therapondos, Hyosun Han, David W. Victor, Sheila Eswaran, Haripriya Maddur, Norah A. Terrault – 18 March 2019 – Alcohol‐associated liver disease (ALD) can be coded in United Network for Organ Sharing (UNOS) as either alcoholic cirrhosis or alcoholic hepatitis (AH), without having specific criteria to assign either diagnosis.

Kelly L. Hayward, Preya J. Patel, Patricia C. Valery, Leigh U. Horsfall, Catherine Y. Li, Penny L. Wright, Caroline J. Tallis, Katherine A. Stuart, Katharine M. Irvine, W. Neil Cottrell, Jennifer H. Martin, Elizabeth E. Powell – 18 March 2019 – People with decompensated cirrhosis are often prescribed a complex regimen of therapeutic and prophylactic medications. In other chronic diseases, polypharmacy increases the risk of medication misadventure and medication‐related problems (MRPs), with associated increased morbidity, mortality, and health care costs.