Cuando la creación de un consorcio proporciona respuestas útiles: experiencia de la Latin American DILI network (LATINDILIN)

Fernando Bessone, Nelia Hernández, Manuel Mendizábal, Adriana Sánchez, Raymundo Paraná, Marco Arrese, Martín Tagle, Marcos Girala, Maribel Lizarzábal, Enrique Carrera, Javier Brahm, Fernando Contreras, Nahum Méndez‐Sánchez, Genario Santos, Vinicius Nunes, Inmaculada Medina‐Cáliz, Cecilio Parra‐Martínez, Laura Sanz‐Villanueva, María Isabel Lucena, Raúl J. Andrade – 29 May 2019

Mammalian Target of Rapamycin Complex 1 Signaling Is Required for the Dedifferentiation From Biliary Cell to Bipotential Progenitor Cell in Zebrafish Liver Regeneration

Jianbo He, Jingying Chen, Xiangyong Wei, Hui Leng, Hongliang Mu, Pengcheng Cai, Lingfei Luo – 28 May 2019 – The liver has a high regenerative capacity. Upon two‐thirds partial hepatectomy, the hepatocytes proliferate and contribute to liver regeneration. After severe liver injury, when the proliferation of residual hepatocytes is blocked, the biliary epithelial cells (BECs) lose their morphology and express hepatoblast and endoderm markers, dedifferentiate into bipotential progenitor cells (BP‐PCs), then proliferate and redifferentiate into mature hepatocytes.

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