HCV in Women and Pregnancy
Nayantara Orekondy, John Cafardi, Tatyana Kushner, Nancy Reau – 28 May 2019
Is Trimming the Fat Enough? Fibroblast Growth Factor 21 as An Emerging Treatment for Nonalcoholic Fatty Liver Disease
Jody Dushay, Michelle Lai – 28 May 2019
HCV in Women and Pregnancy
Nayantara Orekondy, John Cafardi, Tatyana Kushner, Nancy Reau – 28 May 2019
Blocking Sodium‐Taurocholate Cotransporting Polypeptide Stimulates Biliary Cholesterol and Phospholipid Secretion in Mice
Reinout L.P. Roscam Abbing, Davor Slijepcevic, Joanne M. Donkers, Rick Havinga, Suzanne Duijst, Coen C. Paulusma, Johan Kuiper, Folkert Kuipers, Albert K. Groen, Ronald P.J. Oude Elferink, Stan F.J. Graaf – 28 May 2019 – Active secretion of bile salts into the canalicular lumen drives bile formation and promotes biliary cholesterol and phospholipid output. Disrupting hepatic bile salt uptake, by inhibition of sodium‐taurocholate cotransporting polypetide (NTCP; Slc10a1) with Myrcludex B, is expected to limit bile salt flux through the liver and thereby to decrease biliary lipid excretion.
A Heterozygous ABCB4, RUNDC3B, and ABCB1 Deletion Associated With Severe Cholestatic Liver Disease in Adulthood
Benedetta Terziroli Beretta‐Piccoli, Richard Thompson, Pierre Foskett, Andreas Cerny, Elisabetta Merlo, Diego Vergani, Anne‐Laure Rougemont, Isabelle Moix, Giorgina Mieli‐Vergani, Michael Morris – 24 May 2019
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Rosalie C. Oey, Manon C. W. Spaander, Henk R. Buuren, Robert A. Man – 24 May 2019
Acetyl‐3‐Aminoethyl Salicylate Ameliorates Hepatic Ischemia/Reperfusion Injury and Liver Graft Survival Through a High‐Mobility Group Box 1/Toll‐Like Receptor 4–Dependent Mechanism
Xing Lai, Junhua Gong, Weiming Wang, Ding Cao, Menghao Wang, Yiming Liu, Hao Wu, Yakun Wu, Yong Chen, Zhong Zeng, Jinzheng Li, Jianping Gong – 24 May 2019 – In liver transplant cases, severe hepatic ischemia/reperfusion injury (HIRI) is a strong predictor of adverse liver graft and overall outcomes. During HIRI, high‐mobility group box 1 (HMGB1) promotes hepatocellular death and proinflammatory cytokine secretion by toll‐like receptor 4 (TLR4).
A Heterozygous ABCB4, RUNDC3B, and ABCB1 Deletion Associated With Severe Cholestatic Liver Disease in Adulthood
Benedetta Terziroli Beretta‐Piccoli, Richard Thompson, Pierre Foskett, Andreas Cerny, Elisabetta Merlo, Diego Vergani, Anne‐Laure Rougemont, Isabelle Moix, Giorgina Mieli‐Vergani, Michael Morris – 24 May 2019
Ablation of Hepatocyte Smad1, Smad5, and Smad8 Causes Severe Tissue Iron Loading and Liver Fibrosis in Mice
Chia‐Yu Wang, Xia Xiao, Abraham Bayer, Yang Xu, Som Dev, Susanna Canali, Anil V. Nair, Ricard Masia, Jodie L. Babitt – 24 May 2019 – A failure of iron to appropriately regulate liver hepcidin production is central to the pathogenesis of hereditary hemochromatosis. SMAD1/5 transcription factors, activated by bone morphogenetic protein (BMP) signaling, are major regulators of hepcidin production in response to iron; however, the role of SMAD8 and the contribution of SMADs to hepcidin production by other systemic cues remain uncertain.
Baseline Level of Hepatitis B Core Antibody Predicts Spontaneous Hepatitis B e Antigen (HBeAg) Seroconversion in HBeAg‐Positive Children With a Normal Alanine Aminotransferase Level
Ho‐Sheng Chen, Jia‐Feng Wu, Tung‐Hung Su, Huey‐Ling Chen, Hong‐Yuan Hsu, Ning‐Shao Xia, Pei‐Jer Chen, Mei‐Hwei Chang – 23 May 2019 – It is not clear whether baseline hepatitis B core antibody (anti‐HBc) level in hepatitis B e antigen (HBeAg)‐positive children with a normal alanine aminotransferase (ALT) level is predictive of spontaneous HBeAg seroconversion.