High Risk of Fatty Liver Disease Amplifies the Alanine Transaminase–Lowering Effect of a HSD17B13 Variant

Helene Gellert‐Kristensen, Børge Grønne Nordestgaard, Anne Tybjærg‐Hansen, Stefan Stender – 3 June 2019 – A common loss‐of‐function variant in HSD17B13 (rs72613567:TA) was recently found to protect from chronic liver disease. Whether the variant confers protection from specific risk factors for liver disease is unclear. We tested the association of rs72613567 with plasma levels of alanine transaminase (ALT) and clinical liver disease and mortality in 111,612 individuals from the Danish general population, including 497 with cirrhosis and 113 with hepatocellular carcinoma.

Tumor Necrosis Factor Receptor–Associated Factor 6 Promotes Hepatocarcinogenesis by Interacting With Histone Deacetylase 3 to Enhance c‐Myc Gene Expression and Protein Stability

Hua Wu, Tian‐Yu Yang, Yi Li, Wen‐Long Ye, Feng Liu, Xiao‐Shun He, Jing‐Ru Wang, Wen‐Juan Gan, Xiu‐Ming Li, Shen Zhang, Yuan‐Yuan Zhao, Jian‐Ming Li – 3 June 2019 – The oncogene c‐Myc is aberrantly expressed and plays a key role in malignant transformation and progression of hepatocellular carcinoma (HCC). Here, we report that c‐Myc is significantly up‐regulated by tumor necrosis factor receptor–associated factor 6 (TRAF6), an E3 ubiquitin ligase, in hepatocarcinogenesis.

Graft‐Versus‐Tumor Effect in Major Histocompatibility Complex–Mismatched Mouse Liver Transplantation

Dongdong Yu, Lidong Wang, Tianchun Wu, Yaohui Zhang, Yang Tian, Yan Wang, Chenwei Cui, Hui Li, Jinhua Zhang, Lin Zhou, Sheng Yan, Shusen Zheng – 1 June 2019 – Liver transplantation (LT) is currently considered an important method in treating hepatocellular carcinoma (HCC) and an alternative treatment for other liver malignancies. Here, we demonstrated that the graft‐versus‐tumor (GVT) effect exists in allogeneic liver transplantation (allo LT).

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