Chronic Kidney Disease in Liver Transplant Candidates: A Rising Burden Impacting Post–Liver Transplant Outcomes

Giuseppe Cullaro, Elizabeth C. Verna, Brian P. Lee, Jennifer C. Lai – 29 November 2019 – The burden of chronic kidney disease (CKD) is rising among patients with cirrhosis, though it is not known what impact this has had on outcomes after liver transplantation (LT). All patients listed for LT in the United States between 2002 and 2017 were analyzed, excluding those listed with Model for End‐Stage Liver Disease (MELD) exceptions. The primary outcome was post‐LT mortality.

Hepatology Highlights

Joseph F. Pisa, Robert S. Brown, Lauren M. Yang, Daryl T.Y. Lau, Brett E. Fortune, Sayed Obaidullah Aseem, Robert E. Schwartz, Nicholas Russo, Vikas Gupta, Muhammad Amir, Giorgio Roccaro, Nidhi Jalan‐Sakrikar, Enis Kostallari, Amaia Navarro‐Corcuera – 29 November 2019

The North American Consortium for the Study of End‐Stage Liver Disease–Acute‐on‐Chronic Liver Failure Score Accurately Predicts Survival: An External Validation Using a National Cohort

Russell Rosenblatt, Nicole Shen, Zaid Tafesh, Shirley Cohen‐Mekelburg, Carl V. Crawford, Sonal Kumar, Catherine Lucero, Robert S. Brown, Arun Jesudian, Brett E. Fortune – 29 November 2019 – Acute‐on‐chronic liver failure (ACLF) carries high short‐term mortality. The North American Consortium for the Study of End‐Stage Liver Disease (NACSELD)–ACLF score, positive if ≥2 organ failures are present, is a bedside tool that predicts short‐term mortality in patients with cirrhosis.

Lipotoxic Hepatocyte‐Derived Exosomal MicroRNA 192‐5p Activates Macrophages Through Rictor/Akt/Forkhead Box Transcription Factor O1 Signaling in Nonalcoholic Fatty Liver Disease

Xiao‐Lin Liu, Qin Pan, Hai‐Xia Cao, Feng‐Zhi Xin, Ze‐Hua Zhao, Rui‐Xu Yang, Jing Zeng, Huiping Zhou, Jian‐Gao Fan – 28 November 2019

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