Biliary Obstruction Promotes Multilineage Differentiation of Hepatic Stem Cells
Mladen I. Yovchev, Edward J. Lee, Waldemar Rodriguez‐Silva, Joseph Locker, Michael Oertel – 23 May 2019 – Because of their high regenerative potential, stem cells are an ideal resource for development of therapies that replace injured tissue mass and restore function in patients with end‐stage liver diseases. Using a rat model of bile duct ligation (BDL) and biliary fibrosis, we investigated cell engraftment, liver repopulation, and ectopic tissue formation after intrasplenic transplantation of epithelial stem/progenitor cells.