Analysis of Host Responses to Hepatitis B and Delta Viral Infections in a Micro‐scalable Hepatic Co‐culture System

Benjamin Y. Winer, Jenna M. Gaska, Gabriel Lipkowitz, Yaron Bram, Amit Parekh, Lance Parsons, Robert Leach, Rohit Jindal, Cheul H. Cho, Anil Shrirao, Eric Novik, Robert E. Schwartz, Alexander Ploss – 17 June 2019 – Hepatitis B virus (HBV) remains a major global health problem with 257 million chronically infected individuals worldwide, of whom approximately 20 million are co‐infected with hepatitis delta virus (HDV).

Patients' Perspectives on Early Liver Transplantation in Alcohol‐Related Liver Disease

Eric Wong, Paul D. Mullins, Jean‐Philippe Wallach, Eric M. Yoshida, Sigfried R. Erb, Jo‐Ann Ford, Charles H. Scudamore, Vladimir Marquez – 17 June 2019 – Liver transplant programs in Canada require a period of 6 months of abstinence from alcohol before considering a patient with liver disease secondary to alcohol for transplantation.

Clinical Impact of Genomic Diversity From Early to Advanced Hepatocellular Carcinoma

Jean‐Charles Nault, Yoann Martin, Stefano Caruso, Théo Z. Hirsch, Quentin Bayard, Julien Calderaro, Cecile Charpy, Christiane Copie‐Bergman, Marianne Ziol, Paulette Bioulac‐Sage, Gabrielle Couchy, Jean‐Frédéric Blanc, Pierre Nahon, Giuliana Amaddeo, Nathalie Ganne‐Carrie, Guillaume Morcrette, Laurence Chiche, Christophe Duvoux, Sandrine Faivre, Alexis Laurent, Sandrine Imbeaud, Sandra Rebouissou, Josep M.

Development of Capsular Fibrosis Beneath the Liver Surface in Humans and Mice

Steven Balog, Yuchang Li, Tomohiro Ogawa, Toshio Miki, Takeshi Saito, Samuel W. French, Kinji Asahina – 17 June 2019 – Glisson's capsule is the connective tissue present in the portal triad as well as beneath the liver surface. Little is known about how Glisson's capsule changes its structure in capsular fibrosis (CF), which is characterized by fibrogenesis beneath the liver surface.

Rural‐Urban Differences in In‐Hospital Mortality Among Admissions for End‐Stage Liver Disease in the United States

Katherine H. Ross, Rachel E. Patzer, David Goldberg, Nicolas H. Osborne, Raymond J. Lynch – 17 June 2019 – Access to quality hospital care is a persistent problem for rural patients. Little is known about disparities between rural and urban populations regarding in‐hospital outcomes for end‐stage liver disease (ESLD) patients. We aimed to determine whether rural ESLD patients experienced higher in‐hospital mortality than urban patients and whether disparities were attributable to the rurality of the patient or the center.

Vessels Encapsulating Tumor Clusters (VETC) Is a Powerful Predictor of Aggressive Hepatocellular Carcinoma

Salvatore Lorenzo Renne, Ha Young Woo, Sarah Allegra, Noemi Rudini, Hirohisa Yano, Matteo Donadon, Luca Viganò, Jun Akiba, Hye Sun Lee, Hyungjin Rhee, Young Nyun Park, Massimo Roncalli, Luca Di Tommaso – 17 June 2019 – We investigated the clinical significance of a vascular growth pattern of hepatocellular carcinoma (HCC), the vessels that encapsulate tumor clusters (VETC), previously linked to HCC metastatic dissemination.

Transient Cold Storage Prior to Normothermic Liver Perfusion May Facilitate Adoption of a Novel Technology

Carlo D. L. Ceresa, David Nasralla, Christopher J. E. Watson, Andrew J. Butler, Constantin C. Coussios, Keziah Crick, Leanne Hodson, Charles Imber, Wayel Jassem, Simon R. Knight, Hynek Mergental, Rutger J. Ploeg, Joerg M. Pollok, Alberto Quaglia, A. M. James Shapiro, Annemarie Weissenbacher, Peter J. Friend – 17 June 2019 – Clinical adoption of normothermic machine perfusion (NMP) may be facilitated by simplifying logistics and reducing costs. This can be achieved by cold storage of livers for transportation to recipient centers before commencing NMP.

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