Charting the Path Forward for Risk Prediction in Liver Transplant for Hepatocellular Carcinoma: International Validation of HALTHCC Among 4,089 Patients

Daniel J. Firl, Kazunari Sasaki, Vatche G. Agopian, Andre Gorgen, Shoko Kimura, Wethit Dumronggittigule, John C. McVey, Samuele Iesari, Gianluca Mennini, Alessandro Vitale, Armin Finkenstedt, Simona Onali, Maria Hoppe‐Lotichius, Giovanni Vennarecci, Tommaso M. Manzia, Daniele Nicolini, Alfonso W. Avolio, Salvatore Agnes, Marco Vivarelli, Giuseppe Tisone, Giuseppe M. Ettorre, Gerd Otto, Emmanuel Tsochatzis, Massimo Rossi, Andre Viveiros, Umberto Cillo, James F.

Sarcopenia in Chronic Liver Disease: Impact on Outcomes

Poh Hwa Ooi, Amber Hager, Vera C. Mazurak, Khaled Dajani, Ravi Bhargava, Susan M. Gilmour, Diana R. Mager – 26 June 2019 – Malnutrition is a common complication in patients with end‐stage liver disease (ESLD) awaiting liver transplantation (LT). Malnutrition and sarcopenia overlap in etiology and outcomes, with sarcopenia being defined as reduced skeletal muscle mass and muscle function.

Copper Deficiency in Liver Diseases: A Case Series and Pathophysiological Considerations

Lei Yu, Iris W. Liou, Scott W. Biggins, Matthew Yeh, Florencia Jalikis, Lingtak‐Neander Chan, Jason Burkhead – 26 June 2019 – Copper is an indispensable trace element. It serves as a cofactor for enzymes involved in cellular energy metabolism, antioxidant defense, iron transport, and fibrogenesis. Although these processes are central in the pathogenesis of liver disorders, few studies have attributed them to copper deficiency.

An Aging Population of Chronic Hepatitis B With Increasing Comorbidities: A Territory‐Wide Study From 2000 to 2017

Grace Lai‐Hung Wong, Vincent Wai‐Sun Wong, Becky Wing‐Yan Yuen, Yee‐Kit Tse, Hester Wing‐Sum Luk, Terry Cheuk‐Fung Yip, Vicki Wing‐Ki Hui, Lilian Yan Liang, Grace Chung‐Yan Lui, Henry Lik‐Yuen Chan – 25 June 2019 – Patients with chronic hepatitis B (CHB) are aging because of improved survival under better health care. This has an important implication on the choice of antiviral treatment (AVT), given that long‐term safety would be a concern in the presence of multiple comorbidities.

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