Mary E. Rinella, Frank Tacke, Arun J. Sanyal, Quentin M. Anstee, on behalf of the participants of the AASLD/EASL Workshop – 9 July 2019 – Nonalcoholic fatty liver disease (NAFLD) is a global public health concern. Its natural history, the development of nonalcoholic steatohepatitis (NASH) and fibrosis, is highly variable, prone to endogenous (e.g., genetics, microbiota) and exogenous (e.g., nutrition, alcohol, physical activity) disease modifiers, and can fluctuate over time. The complexity of its pathophysiology is reflected by the multitude of pharmacological targets in development.

Kyle E. Korolowizc, Bin Li, Xu Huang, Changsuek Yon, Evelyn Rodrigo, Manny Corpuz, David M. Plouffe, Bhaskar V. Kallakury, Manasa Suresh, Tom Y.‐H. Wu, Andrew T. Miller, Stephan Menne – 8 July 2019 – Current therapeutics for chronic infection with hepatitis B virus (HBV) rarely induce functional cure due to the immunotolerant status of patients. Small molecule agonists targeting toll‐like receptor 7 (TLR7) have been shown to elicit a functional cure in animal models of HBV but sometimes with poor tolerability due to immune‐related toxicities.

Rianne A. Weersink, Joost P.H. Drenth, Nicole G.M. Hunfeld, Sander D. Borgsteede – 8 July 2019

Marie Sinclair, Brooke Chapman, Rudolf Hoermann, Peter W. Angus, Adam Testro, Thomas Scodellaro, Paul J. Gow – 8 July 2019 – Sarcopenia is associated with mortality in cirrhosis, but there is no gold standard for its diagnosis. The comparative utility of different diagnostic methods is unknown. This single‐center observational cohort study followed 145 men referred for liver transplant evaluation between 2005 and 2012.

Alexandre Louvet, Aleksander Krag – 6 July 2019

Yongzhen Liu, Hui Liu, Zhanying Hu, Yang Ding, Xiao‐Ben Pan, Jun Zou, Jingyuan Xi, Guangxin Yu, Hongxin Huang, Meng‐Ting Luo, Fang Guo, Shuang Liu, Qiuju Sheng, Jidong Jia, Yong‐Tang Zheng, Jie Wang, Xiangmei Chen, Ju‐Tao Guo, Lai Wei, Fengmin Lu – 6 July 2019 – Nucleos(t)ide analogues (NAs) have been widely used for the treatment of chronic hepatitis B (CHB). Because viral DNA polymerase lacks proofreading function (3′ exonuclease activity), theoretically, the incorporated NAs would irreversibly terminate viral DNA synthesis.

Lindsey Kennedy, Heather Francis, Gianfranco Alpini – 5 July 2019

Young‐Dong Yu, Regina Hwang, Karim J. Halazun, Adam Griesemer, Tomoaki Kato, Jean Emond, Benjamin Samstein – 5 July 2019

Tiffany C. Lee, Tiffany E. Kaiser, Keith Luckett, Koffi Wima, Leah K. Winer, Mackenzie C. Morris, Al‐Faraaz Kassam, Kamran Safdar, Khurram Bari, Nadeem Anwar, R. Cutler Quillin, Shimul A. Shah – 5 July 2019

Lars Cornelis Pietersen, Elise Sarton, Ian Alwayn, Hwai‐Ding Lam, Hein Putter, Bart Hoek, Andries Erik Braat – 5 July 2019 – The use of a temporary portocaval shunt (TPCS) as well as the order of reperfusion (initial arterial reperfusion [IAR] versus initial portal reperfusion) in orthotopic liver transplantation (OLT) is controversial and, therefore, still under debate.