Older Donor Age Is a Risk Factor for Negative Outcomes After Adult Living Donor Liver Transplantation Using Small‐for‐Size Grafts

Mahmoud Macshut, Toshimi Kaido, Siyuan Yao, Shintaro Yagi, Takashi Ito, Naoko Kamo, Kazuyuki Nagai, Mohamed Sharshar, Shinji Uemoto – 12 July 2019 – Adult‐to‐adult living donor liver transplantation (ALDLT) using small‐for‐size grafts (SFSGs), ie, a graft with a graft‐to‐recipient weight ratio (GRWR) <0.8%, has been a challenge that should be carefully dealt with, and risk factors in this category are unclear. Therefore, we aimed to examine the risk factors and outcomes of ALDLT using SFSGs over a 13‐year period in 121 patients who had undergone their first ALDLT using SFSGs.

Hepatitis C Screening in an Underserved U.S. Cohort of Reproductive Age Women

Nicole J. Kim, Daniel Holguin, Dylan Bush, Mandana Khalili – 11 July 2019 – The opioid epidemic has recently increased the rates of hepatitis C virus (HCV) infection among young women. We therefore aimed to characterize the cascade of HCV care in a cohort of underserved women of reproductive age. Medical records of 19,121 women between the ages of 15 and 44 years, receiving primary care in the San Francisco safety‐net health care system, were reviewed.

Hepatitis C Screening in an Underserved U.S. Cohort of Reproductive Age Women

Nicole J. Kim, Daniel Holguin, Dylan Bush, Mandana Khalili – 11 July 2019 – The opioid epidemic has recently increased the rates of hepatitis C virus (HCV) infection among young women. We therefore aimed to characterize the cascade of HCV care in a cohort of underserved women of reproductive age. Medical records of 19,121 women between the ages of 15 and 44 years, receiving primary care in the San Francisco safety‐net health care system, were reviewed.

Defining the Minimum Acceptable Diagnostic Accuracy of Noninvasive Fibrosis Testing in Cirrhosis: A Decision Analytic Modeling Study

Avik Majumdar, Sara Campos, Kurinchi Gurusamy, Massimo Pinzani, Emmanuel A. Tsochatzis – 11 July 2019 – No studies explore the clinical consequences of using noninvasive tests (NITs) compared to liver biopsy (LB) in diagnosing cirrhosis. Our aim was to combine two decision analytic models to determine the minimum diagnostic accuracy criteria for NITs to diagnose cirrhosis with equivalence to LB in terms of mortality. We further evaluated selected existing NITs used alone and sequentially.

Characterization of Cellular Sources and Circulating Levels of Extracellular Vesicles in a Dietary Murine Model of Nonalcoholic Steatohepatitis

Jiahui Li, Huimin Liu, Amy S. Mauer, Fabrice Lucien, Abagail Raiter, Harikrishna Bandla, Taofic Mounajjed, Ziying Yin, Kevin J. Glaser, Meng Yin, Harmeet Malhi – 10 July 2019 – Circulating extracellular vesicles (EVs) are a novel and emerging biomarker for nonalcoholic steatohepatitis (NASH). It has been demonstrated that total circulating EVs and hepatocyte‐derived EVs are elevated in male mice with diet‐induced NASH. How hepatocyte‐derived EVs change over time and other cellular sources of EVs in NASH have not been determined.

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Kelly L. Hayward, Patricia C. Valery, W. Neil Cottrell, Katharine M. Irvine, Jennifer H. Martin, Elizabeth E. Powell – 10 July 2019

LiverLearning®: 2019 Webinar: Evaluation of Renal Dysfunction and Hyponatremia in Patients with Cirrhosis

This webinar will discuss the management of renal insufficiency in patients with cirrhosis, in both the inpatient and outpatient settings. Topics to be discussed include workup of the patient with acute kidney injury in the outpatient setting, management of diuretics and evaluation using novel biomarkers.

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