Hepatitis B Virus Virions Produced Under Nucleos(t)ide Analogue Treatment Are Mainly Not Infectious Because of Irreversible DNA Chain Termination

Yongzhen Liu, Hui Liu, Zhanying Hu, Yang Ding, Xiao‐Ben Pan, Jun Zou, Jingyuan Xi, Guangxin Yu, Hongxin Huang, Meng‐Ting Luo, Fang Guo, Shuang Liu, Qiuju Sheng, Jidong Jia, Yong‐Tang Zheng, Jie Wang, Xiangmei Chen, Ju‐Tao Guo, Lai Wei, Fengmin Lu – 6 July 2019 – Nucleos(t)ide analogues (NAs) have been widely used for the treatment of chronic hepatitis B (CHB). Because viral DNA polymerase lacks proofreading function (3′ exonuclease activity), theoretically, the incorporated NAs would irreversibly terminate viral DNA synthesis.

Impact of Temporary Portocaval Shunting and Initial Arterial Reperfusion in Orthotopic Liver Transplantation

Lars Cornelis Pietersen, Elise Sarton, Ian Alwayn, Hwai‐Ding Lam, Hein Putter, Bart Hoek, Andries Erik Braat – 5 July 2019 – The use of a temporary portocaval shunt (TPCS) as well as the order of reperfusion (initial arterial reperfusion [IAR] versus initial portal reperfusion) in orthotopic liver transplantation (OLT) is controversial and, therefore, still under debate.

Black Adult Patients With Acute Liver Failure Are Sicker and More Likely to Undergo Liver Transplantation Than White Patients

Lauren Nephew, Zahra Zia, Marwan Ghabril, Eric Orman, Craig Lammert, Naga Chalasani – 4 July 2019 – Racial and ethnic differences in the presentation and outcomes of patients wait‐listed with acute liver failure (ALF) have not been explored. Adult patients with ALF wait‐listed for liver transplantation (LT) from 2002 to 2016 were investigated using the United Network for Organ Sharing database. Clinical characteristics and causative etiologies were compared between white, black, Hispanic, and Asian patients with ALF who were wait‐listed as status 1.

Noninvasive Tests Accurately Identify Advanced Fibrosis due to NASH: Baseline Data From the STELLAR Trials

Quentin M. Anstee, Eric J. Lawitz, Naim Alkhouri, Vincent Wai‐Sun Wong, Manuel Romero‐Gomez, Takeshi Okanoue, Michael Trauner, Kathryn Kersey, Georgia Li, Ling Han, Catherine Jia, Lulu Wang, Guang Chen, G. Mani Subramanian, Robert P. Myers, C. Stephen Djedjos, Anita Kohli, Natalie Bzowej, Ziad Younes, Shiv Sarin, Mitchell L. Shiffman, Stephen A. Harrison, Nezam H. Afdhal, Zachary Goodman, Zobair M. Younossi – 4 July 2019 – Accurate noninvasive tests (NITs) are needed to replace liver biopsy for identifying advanced fibrosis caused by nonalcoholic steatohepatitis (NASH).

One‐Year Recipient Morbidity of Liver Transplantation Using Pure Laparoscopic Versus Open Living Donor Right Hepatectomy: Propensity Score Analysis

Jungchan Park, Choon Hyuck David Kwon, Gyu‐Seong Choi, Suk‐Koo Lee, Jong Man Kim, Jongwook Oh, Young Jae Chung, Kyeong Sik Kim, Ji Soo Lee, Kyo Won Lee, Gaab Soo Kim, Mi Sook Gwak, Justin Sangwook Ko, Ji‐Hye Kwon, Keoungah Kim, Seung Hwan Lee, Jae Won Joh – 4 July 2019 – Donor safety and graft results of pure laparoscopic living donor right hepatectomy (LLDRH) have previously been compared with those of open living donor right hepatectomy (OLDRH). However, the clinical outcomes of recipients at 1‐year follow‐up have never been accurately compared.

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