Intraoperative Troponin Elevation in Liver Transplantation Is Independently Associated With Mortality: A Prospective Observational Study

Almudena L. Vilchez‐Monge, Ignacio Garutti, Concepción Jimeno, Matilde Zaballos, Consuelo Jimenez, Luis Olmedilla, Patricia Piñeiro, Patricia Duque, Magdalena Salcedo, Jose M. Asencio, Jose A Lopez‐Baena, Przemyslaw Maruszewski, Rafael Bañares, Jose M. Perez‐Peña – 16 January 2020 – Intraoperative factors implicated in postoperative mortality after liver transplantation (LT) are poorly understood. Because LT is a particularly demanding procedure, we hypothesized that intraoperative myocardial injury may be frequent and independently associated with early postoperative outcomes.

Pregnancy in Liver Transplantation

Mussarat N. Rahim, Lisa Long, Leonie Penna, Catherine Williamson, Nikos A. Kametas, Kypros H. Nicolaides, Michael A. Heneghan – 16 January 2020 – Pregnancy after liver transplantation (LT) is increasingly common and is a frequent scenario that transplant physicians, obstetricians, and midwives encounter. This review summarizes the key issues surrounding preconception, pregnancy‐related outcomes, immunosuppression, and breastfeeding in female LT recipients.

Phenotypic, Transcriptional, and Functional Analysis of Liver Mesenchymal Stromal Cells and Their Immunomodulatory Properties

Timucin Taner, Nitin Abrol, Walter D. Park, Michael J. Hansen, Michael P. Gustafson, Lilach O. Lerman, Andre J. Wijnen, Allan B. Dietz, Gregory J. Gores, Mark D. Stegall – 16 January 2020 – The liver is an immunologically active organ with a tolerogenic microenvironment at a quiescent state. The immunoregulatory properties of the liver appear to be retained after transplantation because liver allografts can reduce alloresponses against other organs that are simultaneously transplanted. Mechanisms of this phenomenon remain unknown.

Nursing Care of Patients With Cirrhosis: The LiverHope Nursing Project

Núria Fabrellas, Marta Carol, Ester Palacio, Marites Aban, Tommaso Lanzillotti, Gea Nicolao, Maria Teresa Chiappa, Vanessa Esnault, Sabine Graf‐Dirmeier, Jeltje Helder, Andrea Gossard, Mireia Lopez, Marta Cervera, Lacey L. Dols, the LiverHope Consortium Investigators – 16 January 2020 – Cirrhosis is a complex disease that is associated with disturbances in different organs besides the liver, including kidneys, heart, arterial circulation, lungs, gut, and brain.

Pirfenidone Is an Agonistic Ligand for PPARα and Improves NASH by Activation of SIRT1/LKB1/pAMPK

Ana Sandoval‐Rodriguez, Hugo Christian Monroy‐Ramirez, Alejandra Meza‐Rios, Jesus Garcia‐Bañuelos, Jose Vera‐Cruz, Jorge Gutiérrez‐Cuevas, Jorge Silva‐Gomez, Bart Staels, Jose Dominguez‐Rosales, Marina Galicia‐Moreno, Monica Vazquez‐Del Mercado, Jose Navarro‐Partida, Arturo Santos‐Garcia, Juan Armendariz‐Borunda – 16 January 2020 – Nonalcoholic steatohepatitis (NASH) is recognized by hepatic lipid accumulation, inflammation, and fibrosis. No studies have evaluated the prolonged‐release pirfenidone (PR‐PFD) properties on NASH features.

Pathogenesis of Nonalcoholic Steatohepatitis: An Overview

Gopanandan Parthasarathy, Xavier Revelo, Harmeet Malhi – 14 January 2020 – Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous group of liver diseases characterized by the accumulation of fat in the liver. The heterogeneity of NAFLD is reflected in a clinical and histologic spectrum where some patients develop isolated steatosis of the liver, termed nonalcoholic fatty liver, whereas others develop hepatocyte injury, ballooning, inflammation, and consequent fibrosis, termed nonalcoholic steatohepatitis (NASH).

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