Daniel M. Chopyk, Johnasha D. Stuart, Matthew G. Zimmerman, Jing Wen, Sanjeev Gumber, Mehul S. Suthar, Manoj Thapa, Mark J. Czaja, Arash Grakoui – 15 July 2019 – Acetaminophen (APAP)‐induced liver injury is the most common cause of acute liver failure (ALF) in the Western world. APAP toxicity progresses to multiorgan dysfunction and thus has broader whole‐body implications. Importantly, greater 30‐day mortality has been observed in liver transplant recipients following ALF due to APAP‐related versus non‐APAP‐related causes. Reasons for this discrepancy have yet to be determined.

Francesca Virginia Bruschi, Thierry Claudel, Matteo Tardelli, Patrick Starlinger, Fabio Marra, Michael Trauner – 15 July 2019 – The patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) I148M variant predisposes to hepatic steatosis and progression to advanced liver injury with development of fibrosis, cirrhosis, and cancer. Hepatic stellate cells (HSCs) drive the wound healing response to chronic injury, and lack of liver X receptor (LXR) signaling exacerbates liver fibrogenesis by impairing HSC cholesterol homeostasis.

Valerio Manno, Alessio Gerussi, Marco Carbone, Giada Minelli, Domenica Taruscio, Susanna Conti, Pietro Invernizzi – 15 July 2019 – Epidemiological studies on primary biliary cholangitis (PBC) have been based primarily on tertiary referral case series. We aimed to estimate the incidence and prevalence and describe comorbidities in hospitalized patients with PBC in Italy using a national hospital‐based data source. Data were extracted from the National Hospital Discharge Database, which includes all Italian individuals discharged from any hospital in the country.

Ju Dong Yang, Fowsiyo Ahmed, Kristin C. Mara, Benyam D. Addissie, Alina M. Allen, Gregory J. Gores, Lewis R. Roberts – 15 July 2019 – Diabetes increases the risk of liver disease progression and cirrhosis development in patients with nonalcoholic steatohepatitis (NASH). The association between diabetes and the risk of hepatocellular carcinoma (HCC) in NASH patients with cirrhosis is not well quantified. All patients with the diagnosis of NASH cirrhosis seen at Mayo Clinic Rochester between January 2006 and December 2015 were identified.

Nidhi Jariwala, Rachel G. Mendoza, Dawn Garcia, Zhao Lai, Mark A. Subler, Jolene J. Windle, Nitai D. Mukhopadhyay, Paul B. Fisher, Yidong Chen, Devanand Sarkar – 15 July 2019 – Oncoprotein staphylococcal nuclease and tudor domain containing 1 (SND1) regulates gene expression at a posttranscriptional level in multiple cancers, including hepatocellular carcinoma (HCC). Staphylococcal nuclease (SN) domains of SND1 function as a ribonuclease (RNase), and the tudor domain facilitates protein–oligonucleotide interaction.

Ramona Nicolau‐Raducu, Yehuda Raveh – 15 July 2019

Mayank Sharma, Douglas A. Simonettos – 15 July 2019

Daniele Dondossola, Umberto Maggi, Giorgio Rossi – 13 July 2019

Ben L. Da, Pallavi Surana, Samuel A. Schueler, Niloofar Y. Jalaly, Natasha Kamal, Sonia Taneja, Anusha Vittal, Christy L. Gilman, Theo Heller, Christopher Koh – 13 July 2019 – With the success of hepatitis C virus (HCV) direct‐acting antiviral therapies, there has been a shift in research focus to the other major chronic liver diseases (CLDs). The use of social media, specifically Twitter, has become a popular platform for understanding public health trends and for performing health care research.

Mar Miserachs, Eberhard Lurz, Aviva Levman, Anand Ghanekar, Mark Cattral, Vicky Ng, David Grant, Yaron Avitzur – 13 July 2019 – Data on postoperative chylous ascites (CA) after pediatric liver transplantation (LT) are scarce. This retrospective study was conducted to identify the incidence, risk factors, management, and outcomes of postoperative CA in a large single‐center pediatric LT cohort (2000‐2016). The study cohort comprised 317 LTs (153 living donors and 164 deceased donors) in 310 recipients with a median age of 2.7 years.