Phenotypic, Transcriptional, and Functional Analysis of Liver Mesenchymal Stromal Cells and Their Immunomodulatory Properties
Timucin Taner, Nitin Abrol, Walter D. Park, Michael J. Hansen, Michael P. Gustafson, Lilach O. Lerman, Andre J. Wijnen, Allan B. Dietz, Gregory J. Gores, Mark D. Stegall – 16 January 2020 – The liver is an immunologically active organ with a tolerogenic microenvironment at a quiescent state. The immunoregulatory properties of the liver appear to be retained after transplantation because liver allografts can reduce alloresponses against other organs that are simultaneously transplanted. Mechanisms of this phenomenon remain unknown.