Immune Checkpoint Axes Are Dysregulated in Patients With Alcoholic Hepatitis
Wei Li, Ying Xia, Jing Yang, Haitao Guo, Guoqing Sun, Arun J. Sanyal, Vijay H. Shah, Yongliang Lou, Xiaoqun Zheng, Naga Chalasani, Qigui Yu – 12 January 2020 – Alcoholic hepatitis (AH) is a severe inflammatory liver disease that develops in some heavy drinkers. The immune system in patients with AH is hyperactive and yet dysfunctional. Here, we investigated whether this immune‐dysregulated state is related to the alcoholic impact on immune checkpoints (ICPs).