Barry B. Goldberg – 1 February 1989

Hilary A. Wynne, Lance H. Cope, Elaine Mutch, Michael D. Rawlins, Kenneth W. Woodhouse, Oliver F. W. James – 1 February 1989 – The aim of this study was to determine the effect of aging upon liver volume and apparent liver blood flow in healthy man. Sixty‐five subjects between 24 and 91 years of age were recruited. Liver volume was quantitated by a gray scale B ultrasound scan method. Apparent liver blood flow was determined from the plasma clearance of indocyanine green, based on an assumption of no change in hepatic extraction of the dye with age.

Marie V. St‐Pierre, Andreas J. Schwab, Carl A. Goresky, Wai‐Fong Lee, K. Sandy Pang – 1 February 1989 – The technique of normal and retrograde rat liver perfusion has been widely used to probe zonal differences in drug‐metabolizing activities. The validity of this approach mandates the same tissue spaces being accessed by substrates during both normal and retrograde perfusions. Using the multiple‐indicator dilution technique, we presently examine the extent to which retrograde perfusion alters the spaces accessible to noneliminated references.

Glorgina Mieli‐Vergani, Ava Lobo‐Yeo, Barbara M. McFarlane, Ian G. McFarlane, Alex P. Mowat, Diego Vergani – 1 February 1989 – Children with primary sclerosing cholangitis or autoimmune chronic active hepatitis have similar high levels of immunoglobulin G and non‐organ‐specific autoantibodies and may have similar histological features.

Christopher K. Daniels, Douglas L. Schmucker, Albert L. Jones – 1 February 1989 – In the rat, asialoorosomucoid and rat dimeric immunoglobulin A are both taken up by hepatocytes via receptor‐mediated endocytosis. The fate of these two proteins, however, differs significantly. Rat dimeric IgA is taken up into smooth vesicles, transported to the bile canaliculus and secreted intact into the bile, whereas asialoglycoproteins are internalized via coated vesicles and transported to lysosomes for degradation.

Marc L. Berger, Rolland C. Reynolds, Herbert K. Hagler, Dennis Bellotto, Dorabeth Parsons, Kevin J. Mulligan, L. Maximilian Buja – 1 February 1989 – Examination of anoxic isolated hepatocytes by light and electron microscopy indicated that initial morphologic changes were largely localized to the periphery of the cells. This early phase consisted of surface bleb formation but was not accompanied by alterations in parameters of plasma membrane integrity (leakage of cellular enzymes, exclusion of trypan blue).

Anna S. F. Lok, Ching‐Lung Lai – 1 January 1989 – Two hundred ninety patients (203 men, 87 women), age 7 to 74 years (mean: 39.1 years), with chronic hepatitis B virus infection, were prospectively followed for a period of 1 to 4 years to determine the value of α‐fetoprotein monitoring in the early detection of hepatocellular carcinoma. At presentation, 66% of the patients were asymptomatic, 19% had chronic hepatitis and 15% had established cirrhosis.

Jorge J. Gumucio – 1 January 1989

Jenny Heathcote, Young‐In Kim, Colina K. Yim, James Lebrocq, Stanley E. Read – 1 January 1989 – Basal levels of the interferon‐associated enzyme 2′,5′‐oligoadenylate synthetase were studied in lymphocytes of 46 patients with acute viral hepatitis and in 46 patients with chronic hepatitis B. Measurement of in vitro production of 2′,5′‐oligoadenylate synthetase following overnight incubation of lymphocytes with exogenous interferon was used to assess functional capacity of the lymphocyte interferon system.

Charles D. Surh, Dean J. Danner, Aftab Ahmed, Ross L. Coppel, Ian R. Mackay, E. Rolland Dickson, M. Eric Gershwin – 1 January 1989 – Antimitochondrial autoantibodies recognizing 68 to 74 and 50 to 52 kD inner membrane mitochondrial antigens are characteristically present in sera of patients with primary biliary cirrhosis. The biochemical identification of the antigens, however, has remained elusive. We report herein that the 52 kD antigen is the dihydrolipoamide acyltransferase of the branched‐chain α‐keto acid dehydrogenase complex.