Richard Moreau, Samuel S. Lee, Antoine Hadengue, Yves Ozier, Christian Sicot, Didier Lebrec – 1 March 1989 – To elucidate the relationship between oxygen transport and uptake in cirrhosis, we studied the effects of three vasoactive drugs that change O2 transport. Systemic hemodynamics, blood gases and lactate concentration were measured in patients with alcoholic cirrhosis before and after intravenous dobutamine, propranolol and nitroglycerin. Nine patients received successively dobutamine and then propranolol. Ten patients received nitroglycerin.

Owen Epstein – 1 March 1989

Ernest Urban, Vincent J. Dindzans, David H. Van Thiel – 1 March 1989 – This is a report of six patients with cirrhosis of the liver in whom primary hyperparathyroidism occurred due to a solitary parathyroid adenoma 3 months to 9 years after undergoing emergency portacaval shunt for hemorrhage from esophageal varices. The presenting symptoms in all six patients were weakness and bone pain. Three patients had a bone fracture after insignificant trauma, one and probably two passed kidney stones, and a duodenal ulcer developed in two.

Dwain L. Thiele – 1 March 1989

Georg A. Mathis, Sandra A. Walls, Paul D'Amico, Thomas F. Gengo, Alphonse E. Sirica – 1 March 1989 – An extensive bile ductular cell hyperplasia with the formation of well‐differentiated bile ductules is the most prominent feature of rat liver at 6 to 15 weeks after bile duct ligation. We have improved our previous cell isolation procedure and are now routinely able to obtain from such livers high yields of viable bile ductular epithelial cells.

Tse‐Ling Fong, Evangelos A. Akriviadis, Bruce A. Runyon, Telfer B. Reynolds – 1 March 1989 – The purposes of this study were (a) to measure serially ascitic fluid polymorphonuclear cell response in treated spontaneous bacterial peritonitis and (b) to determine whether an ascitic fluid polymorphonuclear cell count of less than 250 per mm3 on serial paracenteses was a satisfactory endpoint for antibiotic therapy.

Craig J. McClain, Donald A. Cohen – 1 March 1989 – Tumor necrosis factor is a cytokine that mediates many of the biologic actions of endotoxin. Recent studies have shown that tumor necrosis factor administration may cause liver injury and that tumor necrosis factor may mediate the lethality of the hepatotoxin galactosamine. One of the most potent inducers of tumor necrosis factor production is endotoxin.

Lawrence I. Deckelbaum – 1 February 1989 – Three cases of hepatic inferior vena cava (IVC) obstruction (two segmental and one membranous) associated with Budd‐Chiari syndrome were successfully treated with percutaneous transluminal angioplasty (PTA) with use of an Nd‐YAG (neodymium‐yttrium, aluminum, garnet) laser. The occluded portions were canalized by advancing a ceramic‐capped delivery system and delivering intermittent laser emissions. The canal was widened by simultaneous inflation of three or four Gruentzig balloon catheters.

Renee C. Lin, Lawrence Lumeng, Vickie L. Phelps – 1 February 1989 – Effects of chronic ethanol consumption on serum lip–oproteins have been studied in the rat. The serum levels of triglycerides, cholesterol, phospholipids and apolipo‐proteins AI and AIV increased significantly after 1 week of ethanol feeding, and they remained elevated up to 7 weeks of alcohol drinking. By contrast, serum total apolipoprotein E decreased or, sometimes, did not change.

Shiro Oguma, Steven Belle, Thomas E. Starzl, A. Jake Demetris – 1 February 1989 – Conspicuous pathologic features of chronic liver allograft rejection include bile duct loss and chronic obliterative arteriopathy. A quantitative histometric analysis was performed to document the extent of bile duct loss, the size of the “vanished” ducts and the extent of chronic obliterative arteriopathy and to determine whether there was any relationship between chronic obliterative arteriopathy and bile duct loss.