Giorgio Senaldi, Giorgina Mieli‐Vergani, Alexander O. Mowat, Diego Vergani – 1 February 1989

David S. Lapointe, Merle S. Olson – 1 February 1989 – Mean transit times for the movement of extracellular and intracellular reference compounds through isolated perfused rat livers were determined during exposure of livers to platelet‐activating factor (AGEPC; 1‐0‐hexa‐decyl‐2‐acetyl‐sn‐glycero‐3‐phosphocholine) and the α‐adrenergic agonist phenylephrine, using the multiple indicator dilution technique.

Robert L. Carithers – 1 February 1989

Hidekazu Tsukamoto, Xiao Ping Xi – 1 February 1989 – Centrilobular hypoxia mediated by enhanced hepatic consumption of oxygen has been hypothesized to be a factor of pathogenetic importance in ethanol‐induced liver injury. In the present study, this hypothesis was tested in a rat model which developed alcoholic centrilobular liver necrosis.

François Kemeny, Jacqueline Vadrot, Andrew Wu, Claude Smadja, Jonathan L. Meakins, Dominique Franco – 1 February 1989 – The pathological findings of 26 consecutive resections for hepatocellular carcinomas developing in cirrhotic patients were analyzed morphologically with a special interest in the presence of a capsule, vascular extension and satellite nodules. Tumor sizes varied from 2 to 11 cm. There were 20 expanding (76.9%) and six infiltrating tumors. Infiltrating tumors were significantly larger than expanding tumors (p<0.01).

J. Eileen Hay, Albert J. Czaja, Jorge Rakela, Jurgen Ludwig – 1 February 1989 – To determine the nature of unexplained chronic serum aspartate aminotransferase elevations of a mild to moderate degree in asymptomatic patients, we performed systematic clinical, biochemical and histologic examinations in 47 individuals who had been screened for virus‐, alcohol‐or drug‐related disease. Serum aspartate aminotransferase levels ranged from 3‐to 8‐fold normal (mean: 156 ± 7 units per liter) for at least 6 months (mean: 30 ± 6 months).

Peter Karayiannis, Lidija M. Petrovic, Mark Fry, Duncan Moore, Mike Enticott, Michael J. McGarvey, Peter J. Scheuer, Howard C. Thomas – 1 February 1989 – Three tamarins (Saguinus labiatus), two of which had previously been infected with hepatitis A virus and parenteral non‐A, non‐B hepatitis, were inoculated intravenously with the agent of GB hepatitis. All three animals developed alanine aminotransferase abnormalities 2, weeks after inoculation. Peak alanine aminotransferase levels were recorded 4 weeks postinoculation.

Michael A. Dunn – 1 February 1989 – Cyclosporin A (CsA), administered subcutaneously as 5 daily injections of 50 mg·kg−1, reduced the numbers of Schistosoma mansoni perfused from MF1 mice at 7 weeks post‐infection. The timing of drug administration revealed that the antischistosomal effects were greater when CsA treatment coincided with or was within a few days of infection with a parasite. CsA exerted a clear prophylactic effect, which decreased with time and was virtually abolished by 4 months pre‐infection. Adult worms treated in vivo were partially susceptible to CsA.

Werner Van Steenbergen, Johan Fevery, Rita De Vos, Roger Leyten, Karel P. M. Heirwegh, Jan De Groote – 1 February 1989 – The effects of thyroidectomy and of thyroid hormone administration on the hepatic transport of endogenous bilirubin were investigated in the Wistar R/APfd rat. Hypothyroidism resulted in an enhanced hepatic bilirubin UDP‐glucuronosyltransferase activity and in a decreased p‐nitrophenol transferase activity. It caused a cholestatic condition with a 50% decrease in bile flow and bile salt excretion, and an increased proportion of conjugated bilirubin in serum.

James E. Heubi, Bruce W. Hollis, Bonny Specker, Reginald C. Tsang – 1 February 1989 – Metabolic bone disease is common in children and adults with chronic cholestasis. We evaluated baseline vitamin D (vitamin D2 and D3), 25‐OH vitamin D2 and D3, 1,25(OH)2 vitamin D, vitamin D‐binding protein, bone mineral content and dietary mineral content in six children (mean age: 12.1 years) with cholestasis since infancy. Absorption of 25‐OH vitamin D3 and vitamin D2 was evaluated by measuring serial serum concentrations after a test dose. Bone mineral content was reduced by >2 S.D.