1 January 1989

Yedy Israel – 1 January 1989

Martin Lombard, Adrian Bomford, Miriam Hynes, Nikolai V. Naoumov, Stephanie Roberts, John Crowe, Roger Williams – 1 January 1989 – The liver is the main site of iron accumulation and pathologic sequelae in hereditary hemochromatosis. Whether this is a result solely of inappropriately increased absorption of iron by the gastrointestinal tract or a more generalized regulatory failure of iron balance is unknown.

Carolyn N. d'Arville, Mysan Le, Thomas M. Kloppel, Francis R. Simon – 1 January 1989 – Reduced hepatic uptake and clearance of macromolecules in liver cirrhosis is due to two major factors: increased diffusional barriers, resulting primarily from the deposition of excessive connective tissue in the space of Disse, and hepatocellular dysfunction, manifested by receptor and/or postreceptor defects.

H. Juergen Nord – 1 January 1989

J. Michael Henderson – 1 January 1989 – Operative ligation of portosystemic shunts is effective in controlling chronic portosystemic encephalopathy (CPSE) but is associated with significant mortality. Review of the records of five paients with CPSE treated with radiologic occlusion procedures showed that these are suitable alternatives to surgery. Three patients had alcoholic cirrhosis, one had hepatic fibrosis from schistosomiasis, and one had post‐necrotic cirrhosis. All had CPSE with progressive, severe cerebral impairment refractory to clinical treatment.

Shou‐Dong Lee, Kwang‐Juei Lo, Yang‐Te Tsai, Jaw‐Ching Wu, Tzee‐Chung Wu – 1 January 1989 – A total of 128 HBsAg carrier infants born to HBeAg‐positive HBsAg carrier mothers were tested for serum HBsAg, HBeAg, hepatitis B virus DNA and anti‐HBc. Ninety‐three of them had received hepatitis B vaccination. Anti‐HBc had been found to be negative in sera of 12 infants who were HBsAg, HBeAg and hepatitis B virus DNA positive during the follow‐up period of 3 to 5 years.

Emilio Barberá‐Guillem, Ricardo Ayala, Fernando Vidal‐Vanaclocha – 1 January 1989 – We have measured the location of embryonic and adult hemopoietic foci in the liver tissue of postnatal and adult phenylhydrazine‐treated mice. Differentiation of acinar domains in liver tissue was made possible by carrying out succinate dehydrogenase histochemical reactions on liver cryostat sections.

Morikazu Onji, Andrew M. L. Lever, Izumu Saito, Howard C. Thomas – 1 January 1989 – The interferon responsiveness of two cell lines transfected with the hepatitis B virus genome was investigated. A cosmid vector containing multiple copies of the hepatitis B virus genome was transfected into FL5‐1 cells; it reduced their sensitivity to interferons as measured by inhibition of the cytopathic effect of Sindbis virus challenge. Similar vectors transfected into HeLa cells reduced their sensitivity to interferon as measured by production of β2‐microglobulin.

Richard B. Jennett, Michael F. Sorrell, Abbas Saffari‐fard, James L. Ockner, Dean J. Tuma – 1 January 1989 – Hepatic ethanol oxidation generates the reactive intermediate acetaldehyde, which binds to proteins. Previous work, using bovine brain tubulin as a model protein, has shown that acetaldehyde preferentially formed stable adducts on the α‐chain of the heterodimeric molecule. This binding resulted in functional impairment of the tubulin/microtubule system as evidenced by a decreased ability of adducted tubulin to form microtubules.