Emilio Barberá‐Guillem, Marian Rocha, Antonia Alvarez, Fernando Vidal‐Vanaclocha – 1 July 1991 – We have studied the distribution patterns of carbohydrate terminals on the endothelial surface of the mouse liver microvasculature. For this purpose, a wide battery of FITC lectins specific to glucose, mannose, galactose, fucose, N‐acetyl‐neuraminic acid, N‐acetylgalactosamine and N‐acetyl‐glucosamine residues were incubated on liver cryostat sections or intraportally perfused under physiological conditions.

Bertram I. Cohen, Nariman Ayyad, Erwin H. Mosbach, Charles K. McSherry, Naoyuki Matoba, Alan F. Hofmann, Huong‐Thu Ton‐Nu, Ying Peng, Claudio D. Schteingart, Richard J. Stenger – 1 July 1991 – The effect of two hydrophilic bile acids, murideoxycholic acid (3α,6β‐dihydroxy‐5β‐cholanoic acid) and ursodeoxycholic acid, on cholesterol and bile acid metabolism and hepatic pathology and gallstone composition was studied in the prairie dog. Cholesterol gallstones were induced by feeding a diet containing 1.2% cholesterol for 75 days.

Miguel Yebra, Felix Lacoma, María Paz Queipo de Llano, María E. Moreno – 1 June 1991

Takuro Hayata, Yoshiyuki Nakano, Kaname Yoshizawa, Takeshi Sodeyama, Kendo Kiyosawa – 1 June 1991 – We investigated the effects of interferon therapy on hepatocyte human leukocyte antigen class I and class II antigen expression and intrahepatic lymphocyte subsets in patients with chronic viral hepatitis B (n = 11) and C (n = 10). Interferon‐α was administered intramuscularly in doses ranging from 3 to 18 million international units daily for 4 wk.

1 June 1991

Jens H. Henriksen, Flemming Bendtsen, Thorkild I. A. Sørensen, Carsten Stadeager, Helmer Ring‐Larsen – 1 June 1991

Kimberly A. Brown, Michael R. Lucey – 1 June 1991 – The effect of successful liver transplantation on menstrual function was assessed by questionnaire in 44 women transplanted for various types of end stage liver disease, acute liver failure or malignant disease. Significant amenorrhoea (>one year) was present in 48% of women with chronic liver disease before transplantation, and was reversed within 10 months of surgery in all but one of the pre‐menopausal patients who had primary amenorrhoea and hypogonadotrophic hypogonadism.

Jose Ribalta, Humberto Reyes, Manuel C. Gonzalez, Joaquin Iglesias, Marco Arrese, Jaime Poniachik, Claudina Molina, Nelly Segovia – 1 June 1991 – S‐Adenosyl‐L‐methionine has been reported to induce beneficial effects in intrahepatic cholestasis of pregnancy. Because cholestasis of pregnancy has a high prevalence in Chile and a deleterious effect on fetal prognosis, we decided to verify the efficacy of S‐adenosyl‐L‐methionine in this disease.

Andrea Crosigani, Mauro Podda, Emanuela Bertolini, Pier Maria Battezzati, Massimo Zuin, Kenneth D. R. Setchell – 1 June 1991 – Ursodeoxycholic acid was administered to a patient with benign recurrent intrahepatic cholestasis to prevent cholestatic episodes. A detailed study of bile acid metabolism in this patient was carried out in the anicteric and icteric phases before and after ursodeoxycholic acid (750 mg/day) administration. Urinary, biliary and serum bile acids were measured by gas chromatography–mass spectrometry and by highperformance liquid chromatography techniques.

T. Jake Liang, Yaacov Baruch, Edna Ben‐Porath, Rafael Enat, Lucyna Bassan, Nancy V. Brown, Nurit Rimon, Hubert E. Blum, Jack R. Wands – 1 June 1991 – We studied 67 HBsAg‐negative Israeli patients (36 negative for all HBV serological markers as group 1 and 31 positive for antibodies to HBs and HBc as group 2) with chronic liver disease and cirrhosis of unknown origin using a rapid, sensitive and specific assay for the detection of low levels of hepatitis B virus in serum.