Shigetoshi Okumura, Yoshiyuki Takei, Sunao Kawano, Kouichi Nagano, Eiji Masuda, Moritaka Goto, Shingo Tsuji, Tomoki Michida, Sheng‐Song Chen, Toru Kashiwagi, Hideyuki Fusamoto, Takenobu Kamada, Nobuhiro Sato – 1 January 1994 – The purpose of this study was to evaluate the role of endothelin‐1 in modulating hepatic microcirculation and liver damage. Rats were infused with endothelin‐1 at doses ranging from 30 to 1,000 pmol/kg over 1 min through an indwelling cannula placed in the portal vein. In control rats, saline solution was infused at the same rate.

Patricia K. Eagon, Mary S. Elm, Elizabeth A. Stafford, Lynne E. Porter – 1 January 1994 – Liver is responsive to sex hormones. The role of androgens in normal human liver function is not well understood, although androgens have been implicated in several liver diseases. Because the human hepatic androgen receptor has not been adequately characterized, we analyzed cytosolic and nuclear fractions from normal human liver of both sexes for androgenbinding activity using multipoint saturation analysis with the androgenic radioligand methyltrienelone (R1881).

Raymond S. Koff – 1 January 1994

Hubert E. Blum – 1 January 1994 – Background and Methods. To detect potentially curable cases of hepatocellular carcinoma, outpatients with chronic hepatitis or compensated liver cirrhosis who were seen at the Center for Adult Diseases (Osaka, Japan) were examined periodically by means of ultrasonography and measurement of serum alpha‐fetoprotein. Risk factors for hepatocellular carcinoma were identified with a Cox proportional‐hazards model.

Xin Xu, Andreas J. Schwab, Ford Barker Iii, Carl A. Goresky, K. Sandy Pang – 1 January 1994 – The hepatocellular entry of salicylamide sulfate conjugate, which binds to both red blood cells and albumin, was examined with the multiple‐indicator dilution technique in the perfused rat liver, with medium containing both 20 red cells and 1 albumin (set A), red cells only (set B), albumin only (set C) and neither red cells nor albumin (set D).

Motoko Sasaki, Naoko Kono, Yasuni Nakanuma – 1 January 1994 – We examined the expression of Lewis antigens, particularly Lewis Y, on the intrahepatic biliary epithelial cells in normal livers and various hepatobiliary diseases with immunohistochemical and immunoelectron microscopic methods. In normal livers, Lewis Y was consistently and generally negative in the bile ductules and small bile ducts, respectively.

Anthony S. Basile, Phil M. Harrison, Robin D. Hughes, Zi‐Quang Gu, Lewis Pannell, Angelique McKinney, E. Anthony Jones, Roger Williams – 1 January 1994 – Levels of benzodiazepine receptor ligands were measured in plasma samples from 25 patients in various stages of hepatic encephalopathy due to fulminant liver failure who were not exposed to pharmaceutical benzodiazepines immediately before or during hospitalization.

Amar P. Dhillon, Andrew K. Burroughs, Mark Hudson, Neil Shah, Keith Rolles, Peter J. Scheuer – 1 January 1994 – Fibrous stenosis of hepatic venules and other features of venous outflow obstruction, including zone 3 congestion and hemorrhage, are sometimes seen after orthotopic liver transplantation. Similar changes associated with endothelial damage have recently been ascribed to azathioprine toxicity and may be forerunners of chronic rejection. Other potential causative agents such as viral hepatitis have yet to be considered.

Loreto Boix, Jose Luis Rosa, Francesc Ventura, Antoni Castells, Jordi Bruix, Joan Rodés, Ramon Bartrons – 1 January 1994 – This study was aimed at assessing the presence of c‐met overexpression in human hepatocellular carcinoma and at determining whether this feature is associated with a definite clinical or pathological characteristic. Expression of c‐met was determined by Northern‐blot hybridization of a specific probe (human met proto‐oncogene) in 18 tumoral and nontumoral liver samples obtained in 18 cirrhotic patients with hepatocellular carcinoma submitted to surgical treatment.

Julián Panés, Josep M. Piqué, Josep M. Bordas, Josep Llach, Jaime Bosch, Josep Terés, Juan Rodés – 1 January 1994 – Gastric mucosal perfusion is increased in portalhypertensive gastropathy, and this may contribute to gastric bleeding from these lesions. Therefore drugs reducing gastric mucosal perfusion may be beneficial in the treatment of overt bleeding from portal‐hypertensive gastropathy.