Jorge E. Cardoso, Chantal Gautreau, Prema Raj Jeyaraj, Dariusz Patrzalek, Brigitte Cherruau, Michel Vaubourdolle, Claire Legendre, Tadeusz Wroblewski, Didier Houssin – 1 February 1994 – In cirrhotic livers, the intrahepatic resistance is increased and drug elimination and portal transhepatic flow are decreased. The aim of our work was to study the effect of a twofold increase in portal blood flow during 2 hr on the hemodynamic parameters, drug elimination and hepatic viability in eight isolated perfused human cirrhotic livers.

Carlo Ferrari, Antonietta Valli, Lucia Galati, Amalia Penna, Patrizia Scaccaglia, Tiziana Giuberti, Claudia Schianchi, Gabriale Missale, Maria Grazia Marin, Franco Fiaccadori – 1 February 1994 – Twenty‐nine patients with chronic hepatitis C and 15 asymptomatic hepatitis C virus antibody–positive subjects who clinically recovered from hepatitis C virus infection were studied for their peripheral blood lymphomononuclear cell proliferative response to hepatitis C virus structural and nonstructural antigens (core, envelope, nonstructural 4 and nonstructural 5) expressed in yeast as superoxide d

Robert H. Schapiro – 1 February 1994 – Injection sclerotherapy of bleeding oesophageal varices is undoubtedly beneficial but it is associated with a substantial complication rate, and variceal rebleeding is common during the treatment period before variceal obliteration is achieved. We aimed to find out whether endoscopic variceal banding ligation is safer and more effective.

Helen F. Goode, Nigel R. Webster, Peter D. Howdle, Jack P. Leek, J. P. A. Lodge, Sammi A. Sadek, Barry E. Walker – 1 February 1994 – Endothelial injury occurs as a result of oxygen free radical production after ischemia and reperfusion of transplanted livers, causing hemodynamic disturbance. Patients with chronic liver disease generally have low levels of fat‐soluble vitamins, which have important antioxidant roles.

Karl T. Benedict – 1 January 1994

Andrea Ewing Reid, T. Jake Liang – 1 January 1994

Shigetoshi Okumura, Yoshiyuki Takei, Sunao Kawano, Kouichi Nagano, Eiji Masuda, Moritaka Goto, Shingo Tsuji, Tomoki Michida, Sheng‐Song Chen, Toru Kashiwagi, Hideyuki Fusamoto, Takenobu Kamada, Nobuhiro Sato – 1 January 1994 – The purpose of this study was to evaluate the role of endothelin‐1 in modulating hepatic microcirculation and liver damage. Rats were infused with endothelin‐1 at doses ranging from 30 to 1,000 pmol/kg over 1 min through an indwelling cannula placed in the portal vein. In control rats, saline solution was infused at the same rate.

Patricia K. Eagon, Mary S. Elm, Elizabeth A. Stafford, Lynne E. Porter – 1 January 1994 – Liver is responsive to sex hormones. The role of androgens in normal human liver function is not well understood, although androgens have been implicated in several liver diseases. Because the human hepatic androgen receptor has not been adequately characterized, we analyzed cytosolic and nuclear fractions from normal human liver of both sexes for androgenbinding activity using multipoint saturation analysis with the androgenic radioligand methyltrienelone (R1881).

Raymond S. Koff – 1 January 1994

Hubert E. Blum – 1 January 1994 – Background and Methods. To detect potentially curable cases of hepatocellular carcinoma, outpatients with chronic hepatitis or compensated liver cirrhosis who were seen at the Center for Adult Diseases (Osaka, Japan) were examined periodically by means of ultrasonography and measurement of serum alpha‐fetoprotein. Risk factors for hepatocellular carcinoma were identified with a Cox proportional‐hazards model.