1 March 1994 – Sera from patients with primary biliary cirrhosis (PBC) react with enzymes of the 2‐oxo dehydrogenase pathways, particularly PDC‐E2. These enzymes are present in all nucleated cells, yet autoimmune damage is confined to biliary epithelial cells. Using a panel of eight mouse monoclonal antibodies and a human combinatorial antibody specific for PDC‐E2, we examined by indirect immunofluorescence and confocal microscopy sections of liver from patients with PBC, progressive sclerosing cholangitis, and hepatocarcinoma.

Ken Zaret – 1 March 1994 – The proto‐oncogene c‐jun is the cellular homologue of v‐jun, the transforming oncogene of the avian sarcoma virus 17. c‐jun encodes one major component of the AP‐1 transcription factor complex and is expressed in many organs during mouse development and in the adult. Because of its rapid induction in cells following growth stimulation and the presence of AP‐1 binding sites in the promoter regions of many genes, the c‐Jun protein is thought to have important functions in cell proliferation and differentiation.

Derek G. Doherty, Peter T. Donaldson, James A. Underhill, J. Mark Farrant, Ann Duthie, Giorgina Mieli‐Vergani, Ian G. McFarlane, Philip J. Johnson, Adrian L. W. F. Eddleston, Alex P. Mowat, Roger Williams – 1 March 1994 – Susceptibility to autoimmune hepatitis in white patients is associated with the human leukocyte antigen class II antigens DR3 and DR4. To analyze the molecular basis of these associations, we used oligonucleotide probes to determine the DRB, DQA and DQB hypervariable nucleotide sequences in 119 patients with autoimmune hepatitis and 177 matched controls.

Alexander S. Petrides, Christoph Vogt, Dirk Schulze‐Berge, Dwight Matthews, Georg Strohmeyer – 1 March 1994 – Glucose intolerance and diabetes mellitus are both prevalent in cirrhosis, yet the pathogenesis of impaired glucose metabolism remains unknown.

Alan J. Young, Gregory M. T. Hare, John B. Hay – 1 March 1994 – The process of lymphocyte migration is required for the systemic dissemination of immunological memory and immune surveillance. We report here experiments to quantitate the normal traffic of lymphocytes that occurs from blood to lymph through the liver and hepatic node in the sheep. Comparisons were made with known lymphocyte homing pools.

Helen F. Goode, Nigel R. Webster, Peter D. Howdle, Jack P. Leek, J. P. A. Lodge, Sammi A. Sadek, Barry E. Walker – 1 February 1994 – Endothelial injury occurs as a result of oxygen free radical production after ischemia and reperfusion of transplanted livers, causing hemodynamic disturbance. Patients with chronic liver disease generally have low levels of fat‐soluble vitamins, which have important antioxidant roles.

Robert H. Schapiro – 1 February 1994 – Injection sclerotherapy of bleeding oesophageal varices is undoubtedly beneficial but it is associated with a substantial complication rate, and variceal rebleeding is common during the treatment period before variceal obliteration is achieved. We aimed to find out whether endoscopic variceal banding ligation is safer and more effective.

Carlo Ferrari, Antonietta Valli, Lucia Galati, Amalia Penna, Patrizia Scaccaglia, Tiziana Giuberti, Claudia Schianchi, Gabriale Missale, Maria Grazia Marin, Franco Fiaccadori – 1 February 1994 – Twenty‐nine patients with chronic hepatitis C and 15 asymptomatic hepatitis C virus antibody–positive subjects who clinically recovered from hepatitis C virus infection were studied for their peripheral blood lymphomononuclear cell proliferative response to hepatitis C virus structural and nonstructural antigens (core, envelope, nonstructural 4 and nonstructural 5) expressed in yeast as superoxide d

Jorge E. Cardoso, Chantal Gautreau, Prema Raj Jeyaraj, Dariusz Patrzalek, Brigitte Cherruau, Michel Vaubourdolle, Claire Legendre, Tadeusz Wroblewski, Didier Houssin – 1 February 1994 – In cirrhotic livers, the intrahepatic resistance is increased and drug elimination and portal transhepatic flow are decreased. The aim of our work was to study the effect of a twofold increase in portal blood flow during 2 hr on the hemodynamic parameters, drug elimination and hepatic viability in eight isolated perfused human cirrhotic livers.

Carlos A. Cosenza, Donald V. Cramer, Scott A. Cunneen, Phillip J. Tuso, Hong K. Wang, Leonard Makowka – 1 February 1994 – Lipid peroxidation may play a major role in the loss of liver graft viability after prolonged cold ischemia and reperfusion injury.