1 February 1994

Steven A. Rogers, Daniel K. Podolsky – 1 February 1994 – Primary sclerosing cholangitis (PSC) predisposes to the development of cholangiocarcinoma, a usually fatal complication that is difficult to diagnose. Serum concentrations of CA 19‐9, a tumor‐associated antigen, are frequently increased in patients with only cholangiocarcinoma. The aim of this study was to assess the value of an increased serum CA 19‐9 level for the diagnosis of cholangiocarcinoma in patients with preexisting PSC.

Michael I. Luster, Dori R. Germolec, Takahiko Yoshida, Fujio Kayama, Morrow Thompson – 1 February 1994 – Peptide mediators, including tumor necrosis factor‐α, interleukin 1 and interleukin‐6, are associated with many chronic inflammatory diseases and septic shock. As such, considerable information has been collected by means of study of cytokine secretion from isolated cells or plasma cytokines during septic shock or inflammatory disorders.

Peretz Weiss, Gilbert Ashwell, Anatol G. Morell, Richard J. Stockert – 1 February 1994 – The hepatic receptor for asialoglycoproteins was found to be modulated by the glucose concentration in the medium of the human hepatoma cell line HepG2. The surface binding of asialoorosomucoid, a well‐documented ligand for this receptor, increased from 20 ng/mg of cellular protein to about 40 ng/mg as the glucose concentration was increased from 10 to 50 mg/dl.

Carlos A. Cosenza, Donald V. Cramer, Scott A. Cunneen, Phillip J. Tuso, Hong K. Wang, Leonard Makowka – 1 February 1994 – Lipid peroxidation may play a major role in the loss of liver graft viability after prolonged cold ischemia and reperfusion injury.

Jorge E. Cardoso, Chantal Gautreau, Prema Raj Jeyaraj, Dariusz Patrzalek, Brigitte Cherruau, Michel Vaubourdolle, Claire Legendre, Tadeusz Wroblewski, Didier Houssin – 1 February 1994 – In cirrhotic livers, the intrahepatic resistance is increased and drug elimination and portal transhepatic flow are decreased. The aim of our work was to study the effect of a twofold increase in portal blood flow during 2 hr on the hemodynamic parameters, drug elimination and hepatic viability in eight isolated perfused human cirrhotic livers.

Carlo Ferrari, Antonietta Valli, Lucia Galati, Amalia Penna, Patrizia Scaccaglia, Tiziana Giuberti, Claudia Schianchi, Gabriale Missale, Maria Grazia Marin, Franco Fiaccadori – 1 February 1994 – Twenty‐nine patients with chronic hepatitis C and 15 asymptomatic hepatitis C virus antibody–positive subjects who clinically recovered from hepatitis C virus infection were studied for their peripheral blood lymphomononuclear cell proliferative response to hepatitis C virus structural and nonstructural antigens (core, envelope, nonstructural 4 and nonstructural 5) expressed in yeast as superoxide d

Robert H. Schapiro – 1 February 1994 – Injection sclerotherapy of bleeding oesophageal varices is undoubtedly beneficial but it is associated with a substantial complication rate, and variceal rebleeding is common during the treatment period before variceal obliteration is achieved. We aimed to find out whether endoscopic variceal banding ligation is safer and more effective.

Helen F. Goode, Nigel R. Webster, Peter D. Howdle, Jack P. Leek, J. P. A. Lodge, Sammi A. Sadek, Barry E. Walker – 1 February 1994 – Endothelial injury occurs as a result of oxygen free radical production after ischemia and reperfusion of transplanted livers, causing hemodynamic disturbance. Patients with chronic liver disease generally have low levels of fat‐soluble vitamins, which have important antioxidant roles.

Karl T. Benedict – 1 January 1994