Polo‐like kinase 4 inhibitor CFI‐400945 suppresses liver cancer through cell cycle perturbation and eliciting antitumor immunity

Cerise Yuen‐Ki Chan, Vincent Wai‐Hin Yuen, David Kung‐Chun Chiu, Chi‐Ching Goh, Kelsie L. Thu, David W. Cescon, Isabel Soria‐Bretones, Cheuk‐Ting Law, Jacinth Wing‐Sum Cheu, Derek Lee, Aki Pui‐Wah Tse, Kel Vin Tan, Misty Shuo Zhang, Bowie Po‐Yee Wong, Chun‐Ming Wong, Pek‐Lan Khong, Irene Oi‐Lin Ng, Mark R. Bray, Tak Wah Mak, Thomas Chung‐Cheung Yau, Carmen Chak‐Lui Wong – 17 March 2022

LiverLearning®: 2022 Webinar: Applications of TIPS for Portal Hypertension: Entering a New Era

This webinar will address endovascular management of portal hypertensive complications using TIPS. Speakers will assess evidence for the use of TIPS in the setting of portal and mesenteric vein thromboses and how this may impact portal HTN, survival, as well as transplant outcomes. Speakers will also discuss the standard and emerging indications for TIPS as well as future directions for TIPS management in portal HTN.Virginia Hernandez-Gea Virginia Hernández-Gea, MD, PhD is a interventional hepatologist at the liver unit at hospital clinic.

C‐C motif chemokine ligand 5 confines liver regeneration by down‐regulating reparative macrophage‐derived hepatocyte growth factor in a forkhead box O 3a–dependent manner

Miao Huang, Junzhe Jiao, Hao Cai, Yichi Zhang, Yuhan Xia, Jiacheng Lin, Zhi Shang, Yihan Qian, Fang Wang, Hailong Wu, Xiaoni Kong, Jinyang Gu – 14 March 2022

Interactions of physical activity, muscular fitness, adiposity, and genetic risk for NAFLD

Theresia M. Schnurr, Sophia Figueroa Katz, Johanne M. Justesen, Jack W. O’Sullivan, Peter Saliba‐Gustafsson, Themistocles L. Assimes, Ivan Carcamo‐Orive, Aijaz Ahmed, Euan A. Ashley, Torben Hansen, Joshua W. Knowles – 14 March 2022 – Genetic predisposition and unhealthy lifestyle are risk factors for nonalcoholic fatty liver disease (NAFLD). We investigated whether the genetic risk of NAFLD is modified by physical activity, muscular fitness, and/or adiposity.

Long‐term follow‐up of living liver donors: A single‐center experience

Ehab E. Abdel‐Khalek, Mohamed Abdel‐Wahab, Mohamed H. Elgazzar, Mahmoud A. Khattab, Abdel‐Hady El‐Gilany, Hesham M. Elgouhari, Ahmed Shehta – 14 March 2022 – Living donors are healthy individuals who are exposed to a major surgical procedure during which a major part of their liver is resected. Data on the long‐term consequences of living liver donation are scarce. This study examined clinical, laboratory, and long‐term health‐related quality of life (HRQoL) in 237 living liver donors and 239 matched controls during 48–168 months of postdonation follow‐up.

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