Transcriptomic profiling of a multiethnic pediatric NAFLD cohort reveals genes and pathways associated with disease

Kangning Yao, Elena Tarabra, Daniela Sia, Raffaella Morotti, Rima Fawaz, Pamela Valentino, Nicola Santoro, Sonia Caprio, Silvia Liu, Dean Yimlamai – 20 March 2022 – Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic liver disease in children. The mechanisms that drive NAFLD disease progression in this specific patient population remain poorly defined. In this study, we obtained liver biopsy samples from a multiethnic cohort of pediatric patients with NAFLD (n = 52, mean age = 13.6 years) and healthy liver controls (n = 5).

Donor–recipient human leukocyte antigen A mismatching is associated with hepatic artery thrombosis, sepsis, graft loss, and reduced survival after liver transplant

Christopher Bricogne, Neil Halliday, Raymond Fernando, Emmanuel A. Tsochatzis, Brian R. Davidson, Mark Harber, Rachel H. Westbrook – 20 March 2022 – Human leukocyte antigen (HLA) matching is not routinely performed for liver transplantation as there is no consistent evidence of benefit; however, the impact of HLA mismatching remains uncertain. We explored the effect of class I and II HLA mismatching on graft failure and mortality. A total of 1042 liver transplants performed at a single center between 1999 and 2016 with available HLA typing data were included.

Hepatic kinome atlas: An in‐depth identification of kinase pathways in liver fibrosis of humans and rodents

Justin F. Creeden, Zachary A. Kipp, Mei Xu, Robert M. Flight, Hunter N. B. Moseley, Genesee J. Martinez, Wang‐Hsin Lee, Khaled Alganem, Ali S. Imami, Megan R. McMullen, Sanjoy Roychowdhury, Atta M. Nawabi, Jennifer A. Hipp, Samir Softic, Steven A. Weinman, Robert McCullumsmith, Laura E. Nagy, Terry D. Hinds – 20 March 2022

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