Sandra De Meyer, Inge Dierynck, Anne Ghys, Maria Beumont, Bjorn Daems, Ben Van Baelen, James C. Sullivan, Douglas J. Bartels, Tara L.
Carlos Fernández‐Hernando – 16 July 2012
Ariel D. Quiroga, Lena Li, Martin Trötzmüller, Randy Nelson, Spencer D. Proctor, Harald Köfeler, Richard Lehner – 16 July 2012 – Increased lipogenesis, together with hyperlipidemia and increased fat deposition, contribute to obesity and associated metabolic disorders including nonalcoholic fatty liver disease. Here we show that carboxylesterase 1/esterase‐x (Ces1/Es‐x) plays a regulatory role in hepatic fat metabolism in the mouse.
Brent A. Neuschwander‐Tetri, David Q.‐H. Wang – 14 July 2012
Drren G. Craig, Kenneth J. Simpson – 14 July 2012
Christopher H. Remien, Frederick R. Adler, Terry D. Box, Lindsey Waddoups, Norman L. Sussman – 14 July 2012
Shaoyong Li, Lianne E.M. Vriend, Imad A. Nasser, Yury Popov, Nezam H. Afdhal, Margaret J. Koziel, Detlef Schuppan, Mark A. Exley, Nadia Alatrakchi – 14 July 2012 – Hepatitis C virus (HCV)‐specific immune effector responses can cause liver damage in chronic infection. Hepatic stellate cells (HSC) are the main effectors of liver fibrosis. TGFβ, produced by HCV‐specific CD8+ T cells, is a key regulatory cytokine modulating HCV‐specific effector T cells.
Massimo Puoti, Maria Cristina Moioli, Roberto Rossotti, Giovanna Travi, Raffaele Bruno – 14 July 2012
Michael E. Mullins, Evan Schwarz – 14 July 2012
Tomonori Aoyama, Yong‐Han Paik, Sumio Watanabe, Benoît Laleu, Francesca Gaggini, Laetitia Fioraso‐Cartier, Sophie Molango, Freddy Heitz, Cédric Merlot, Cédric Szyndralewiez, Patrick Page, David A. Brenner – 14 July 2012 – Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) generates reactive oxygen species (ROS) in hepatic stellate cells (HSCs) during liver fibrosis. In response to fibrogenic agonists, such as angiotensin II (Ang II), the NOX1 components form an active complex, including Ras‐related botulinum toxin substrate 1 (Rac1).