Glycogen synthase kinase 3‐mediated voltage‐dependent anion channel phosphorylation controls outer mitochondrial membrane permeability during lipid accumulation

Cecile Martel, Maya Allouche, Davide Degli Esposti, Elena Fanelli, Céline Boursier, Céline Henry, Joel Chopineau, Giuseppe Calamita, Guido Kroemer, Antoinette Lemoine, Catherine Brenner – 19 July 2012 – Nonalcoholic steatosis is a liver pathology characterized by fat accumulation and severe metabolic alterations involving early mitochondrial impairment and late hepatocyte cell death. However, mitochondrial dysfunction mechanisms remain elusive.

TIE2‐expressing monocytes as a diagnostic marker for hepatocellular carcinoma correlates with angiogenesis

Tokuhiro Matsubara, Tatsuya Kanto, Shoko Kuroda, Sachiyo Yoshio, Koyo Higashitani, Naruyasu Kakita, Masanori Miyazaki, Mitsuru Sakakibara, Naoki Hiramatsu, Akinori Kasahara, Yoshito Tomimaru, Akira Tomokuni, Hiroaki Nagano, Norio Hayashi, Tetsuo Takehara – 19 July 2012 – Angiogenesis is a critical step in the development and progression of hepatocellular carcinoma (HCC). Myeloid lineage cells, such as macrophages and monocytes, have been reported to regulate angiogenesis in mouse tumor models.

Decrease of microRNA‐122 causes hepatic insulin resistance by inducing protein tyrosine phosphatase 1B, which is reversed by licorice flavonoid

Yoon Mee Yang, So Yeon Seo, Tae Hyun Kim, Sang Geon Kim – 17 July 2012 – Protein tyrosine phosphatase 1B (PTP1B) inhibits hepatic insulin signaling by dephosphorylating tyrosine residues in insulin receptor (IR) and insulin receptor substrate (IRS). MicroRNAs may modulate metabolic functions. In view of the lack of understanding of the regulatory mechanism of PTP1B and its chemical inhibitors, this study investigated whether dysregulation of specific microRNA causes PTP1B‐mediated hepatic insulin resistance, and if so, what the underlying basis is.

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