Efficacy of antiviral therapy for hepatitis C after liver transplantation with cyclosporine and tacrolimus: A systematic review and meta‐analysis

Rania Rabie, Khalid Mumtaz, Eberhard L. Renner – 23 July 2012 – Cyclosporine A (CSA), but not tacrolimus (TAC), inhibits hepatitis C virus (HCV) replication in vitro. Clinical reports on the efficacy of interferon‐α (IFNα)–based antiviral therapy (AVT) for recurrent HCV after liver transplantation (LT) with CSA and TAC are conflicting. Our aim was to assess whether AVT for recurrent HCV after LT is more effective with CSA or TAC. We performed an electronic database search (1995‐2012) and a manual abstract search (2005‐2012).

MicroRNA‐221 overexpression accelerates hepatocyte proliferation during liver regeneration

Qinggong Yuan, Komal Loya, Bhavna Rani, Selina Möbus, Asha Balakrishnan, Jutta Lamle, Toni Cathomen, Arndt Vogel, Michael P. Manns, Michael Ott, Tobias Cantz, Amar Deep Sharma – 23 July 2012 – The tightly controlled replication of hepatocytes in liver regeneration and uncontrolled proliferation of tumor cells in hepatocellular carcinoma (HCC) are often modulated by common regulatory pathways. Several microRNAs (miRNAs) are involved in HCC progression by modulating posttranscriptional expression of multiple target genes.

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