Ho‐Geol Ryu, Chul‐Woo Jung, Hyung‐Chul Lee, Youn‐Joung Cho – 23 July 2012 – Acute hypotension after reperfusion of the liver graft occurs frequently during liver transplantation. A randomized, prospective trial was performed to test the effects of epinephrine and phenylephrine pretreatments for attenuating postreperfusion syndrome (PRS). Ninety‐three adult liver recipients were randomly allocated to receive an intravenous bolus of 10 μg of epinephrine, 100 μg of phenylephrine, or normal saline (the control group) at the time of graft reperfusion.

Michael J. Englesbe – 23 July 2012

Wolfram Goessling – 23 July 2012

Gregory T. Everson, Norah A. Terrault, Anna S. Lok, Del R. Rodrigo, Robert S. Brown, Sammy Saab, Mitchell L. Shiffman, Abdullah M.S. Al‐Osaimi, Laura M. Kulik, Brenda W. Gillespie, James E. Everhart, and the Adult‐to‐Adult Living Donor Liver Transplantation Cohort Study – 23 July 2012 – Hepatitis C virus (HCV) infection recurs in liver recipients who are viremic at transplantation. We conducted a randomized, controlled trial to test the efficacy and safety of pretransplant pegylated interferon alpha‐2b plus ribavirin (Peg‐IFN‐α2b/RBV) for prevention of post‐transplant HCV recurrence.

Douglas Mogul, Kathleen B. Schwarz – 23 July 2012 – Watch an interview with Dr. Schwarz

Daming Zuo, Xiaofei Yu, Chunqing Guo, Hongxia Wang, Jie Qian, Huanfa Yi, Xiao Lu, Zhi‐Ping Lv, John R. Subjeck, Huiping Zhou, Arun J. Sanyal, Zhengliang Chen, Xiang‐Yang Wang – 23 July 2012 – Negative feedback immune mechanisms are essential for maintenance of hepatic homeostasis and prevention of immune‐mediated liver injury. We show here that scavenger receptor A (SRA/CD204), a pattern recognition molecule, is highly up‐regulated in the livers of patients with autoimmune or viral hepatitis, and of mice during concanavalin A (Con A)‐induced hepatitis (CIH).

Karen M.F. Sze, Glanice K.Y. Chu, Joyce M.F. Lee, Irene O.L. Ng – 23 July 2012 – Random integration of hepatitis B virus (HBV) DNA into the host genome is frequent in human hepatocellular carcinoma (HCC) and this leads to truncation of the HBV DNA, particularly at the C‐terminal end of the HBV X protein (HBx). In this study, we investigated the frequency of this natural C‐terminal truncation of HBx in human HCCs and its functional significance. In 50 HBV‐positive patients with HCC, full‐length HBx was detected in all nontumorous livers.

Elizabeth C. Verna, Robert S. Brown – 23 July 2012 – Watch the interview with the authors

Ranjeeta Bahirwani, K. Rajender Reddy – 23 July 2012 – Watch the interview with the authors

David C. Mulligan – 23 July 2012