Hepatic loss of survivin impairs postnatal liver development and promotes expansion of hepatic progenitor cells in mice

Dan Li, Jin Cen, Xiaotao Chen, Edward M. Conway, Yuan Ji, Lijian Hui – 28 June 2013 – Hepatocytes possess a remarkable capacity to regenerate and reconstitute the parenchyma after liver damage. However, in the case of chronic injury, their proliferative potential is impaired and hepatic progenitor cells (HPCs) are activated, resulting in a ductular reaction known as oval cell response. Proapoptotic and survival signals maintain a precise balance to spare hepatocytes and progenitors from hyperplasia and cell death during regeneration.

Transfusion of older red blood cells is associated with decreased graft survival after orthotopic liver transplantation

Jacek B. Cywinski, Jing You, Maged Argalious, Samuel Irefin, Brian M. Parker, John J. Fung, Colleen G. Koch – 27 June 2013 – Investigations have demonstrated conflicting results regarding the influence of the red blood cell (RBC) storage duration on outcomes. We evaluated whether graft failure or mortality after orthotopic liver transplantation (OLT) increased when recipients were transfused with older RBCs. This study included 637 patients who underwent OLT between January 2001 and June 2011.

Liver transplantation with a strongly positive crossmatch: Case study and literature review

Garrett R. Leonard, Hiroko Shike, Tadahiro Uemura, Justine L. Gaspari, Francesca M. Ruggiero, Riaz A. Shah, Thomas R. Riley, Zakiyah Kadry – 24 June 2013 – A positive crossmatch has been associated with increased risk in liver transplantation. To study the clinical significance of preformed donor‐specific human leukocyte antigen antibodies (DSAs) in liver transplantation, we reviewed patients who underwent liver transplantation with a strongly positive flow cytometry crossmatch. DSAs were evaluated with a Luminex solid phase assay.

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