Maria J. Amaya, André G. Oliveira, Erika S. Guimarães, Marisa C.F. Casteluber, Sandhra M. Carvalho, Lidia M. Andrade, Mauro C.X. Pinto, Albert Mennone, Cleida A. Oliveira, Rodrigo R. Resende, Gustavo B. Menezes, Michael H. Nathanson, M. Fatima Leite – 9 July 2013 – Insulin's metabolic effects in the liver are widely appreciated, but insulin's ability to act as a hepatic mitogen is less well understood.
Sílvia Vilarinho, Tamar H. Taddei – 8 July 2013
Andrei Turtoi, Arnaud Blomme, Delphine Debois, Joan Somja, David Delvaux, Georgios Patsos, Emmanuel Valentin, Olivier Peulen, Eugène Nzaramba Mutijima, Edwin Pauw, Philippe Delvenne, Olivier Detry, Vincent Castronovo – 6 July 2013 – Tumor heterogeneity is a major obstacle for developing effective anticancer treatments. Recent studies have pointed to large stochastic genetic heterogeneity within cancer lesions, where no pattern seems to exist that would enable a more structured targeted therapy approach.
Resat Cinar, Grzegorz Godlewski, Jie Liu, Joseph Tam, Tony Jourdan, Bani Mukhopadhyay, Judith Harvey‐White, George Kunos – 6 July 2013 – Obesity is associated with increased activity of two lipid signaling systems (endocannabinoids [ECs] and ceramides), with both being implicated in insulin resistance. Cannabinoid‐1 receptor (CB1R) antagonists reverse obesity and insulin resistance, but have psychiatric side effects.
Kengo Tomita, Toshiaki Teratani, Takahiro Suzuki, Motonori Shimizu, Hirokazu Sato, Kazuyuki Narimatsu, Yoshikiyo Okada, Chie Kurihara, Rie Irie, Hirokazu Yokoyama, Katsuyoshi Shimamura, Shingo Usui, Hirotoshi Ebinuma, Hidetsugu Saito, Chikako Watanabe, Shunsuke Komoto, Atsushi Kawaguchi, Shigeaki Nagao, Kazuo Sugiyama, Ryota Hokari, Takanori Kanai, Soichiro Miura, Toshifumi Hibi – 6 July 2013 – Although nonalcoholic steatohepatitis (NASH) is associated with hypercholesterolemia, the underlying mechanisms of this association have not been clarified.
Jinghong Wan, Merieme Benkdane, Fatima Teixeira‐Clerc, Stéphanie Bonnafous, Alexandre Louvet, Fouad Lafdil, Françoise Pecker, Albert Tran, Philippe Gual, Ariane Mallat, Sophie Lotersztajn, Catherine Pavoine – 6 July 2013 – Alcoholic and nonalcoholic fatty liver disease (ALD and NAFLD) are the predominant causes of liver‐related mortality in Western countries. We have shown that limiting classical (M1) Kupffer cell (KC) polarization reduces alcohol‐induced liver injury. Herein, we investigated whether favoring alternatively activated M2 KCs may protect against ALD and NAFLD.
C. Kristian Enestvedt, Saloni Malik, Peter P. Reese, Alexander Maskin, Peter S. Yoo, Sameh A. Fayek, Peter Abt, Kim M. Olthoff, Abraham Shaked – 2 July 2013 – Inferior outcomes are consistently observed for recipients of liver retransplantation (re‐LT) versus recipients of primary transplants. Few studies have examined the incidence and impact of biliary complications (BCs) on outcomes after re‐LT. The aim of this study was to compare patient and graft survival for re‐LT recipients with BCs (BC+) and re‐LT recipients without BCs (BC−).
Stefan Mauss, Dietrich Hueppe, Ulrich Alshuth – 28 June 2013 – In clinical trials with telaprevir (TLV) and boceprevir (BOC) renal impairment was not reported as a relevant adverse event. The PAN study is a noninterventional study enrolling patients treated with peginterferon alfa‐2a/ribavirin (PEG/RBV) with or without TVL or BOC. Here we restrict the analysis to hepatitis C virus genotype 1 patients having completed 12 (n = 895) or 24 weeks (n = 591) of treatment.
Peter Fickert, Elisabeth Krones, Marion J. Pollheimer, Andrea Thueringer, Tarek Moustafa, Dagmar Silbert, Emina Halilbasic, Min Yang, Hartmut Jaeschke, Geurt Stokman, Rebecca G. Wells, Kathrin Eller, Alexander R. Rosenkranz, Gosta Eggertsen, Carsten A. Wagner, Cord Langner, Helmut Denk, Michael Trauner – 28 June 2013 – Tubular epithelial injury represents an underestimated but important cause of renal dysfunction in patients with cholestasis and advanced liver disease, but the underlying mechanisms are unclear.