Randomized, double‐blind, controlled study of glycerol phenylbutyrate in hepatic encephalopathy

Don C. Rockey, John M. Vierling, Parvez Mantry, Marwan Ghabril, Robert S. Brown, Olga Alexeeva, Igor A. Zupanets, Vladimir Grinevich, Andrey Baranovsky, Larysa Dudar, Galyna Fadieienko, Nataliya Kharchenko, Iryna Klaryts'ka, Vyacheslav Morozov, Priya Grewal, Timothy McCashland, K. Gautham Reddy, K. Rajender Reddy, Vasyl Syplyviy, Nathan M. Bass, Klara Dickinson, Catherine Norris, Dion Coakley, Masoud Mokhtarani, Bruce F.

Repopulation of the fibrotic/cirrhotic rat liver by transplanted hepatic stem/progenitor cells and mature hepatocytes

Mladen I. Yovchev, Yuhua Xue, David A. Shafritz, Joseph Locker, Michael Oertel – 10 July 2013 – Considerable progress has been made in developing antifibrotic agents and other strategies to treat liver fibrosis; however, significant long‐term restoration of functional liver mass has not yet been achieved. Therefore, we investigated whether transplanted hepatic stem/progenitor cells can effectively repopulate the liver with advanced fibrosis/cirrhosis.

Relationship between the histological appearance of the portal vein and development of ischemic‐type biliary lesions after liver transplantation

Waqar R. R. Farid, Jeroen Jonge, Pieter E. Zondervan, Ahmet Demirkiran, Herold J. Metselaar, Hugo W. Tilanus, Ron W. F. Bruin, Luc J. W. Laan, Geert Kazemier – 10 July 2013 – Ischemic‐type biliary lesions (ITBLs) are a major cause of morbidity after liver transplantation (LT). Their assumed underlying pathophysiological mechanism is ischemia/reperfusion injury of the biliary tree, in which the portal circulation has been proposed recently to have a role.

Endogenous signal transducer and activator of transcription 3 is required for the protection of hepatocytes against warm ischemia/reperfusion injury

Lucy Xi Lou, Tadahiro Uemura, Haresh Mani, Chen Yang, Weiyi Li, Zakiyah Kadry, Samuel Shao‐Min Zhang – 9 July 2013 – Warm ischemia/reperfusion (I/R) is a common clinical problem during liver transplantation and liver resection. Warm ischemia also occurs during trauma and shock. However, there is still no safe and promising strategy for protecting the liver from I/R injury. Signal transducer and activator of transcription 3 (STAT3) is a major immediate response molecule for protecting cell survival.

Long‐term medical management of the pediatric patient after liver transplantation: 2013 practice guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation

Deirdre A. Kelly, John C. Bucuvalas, Estella M. Alonso, Saul J. Karpen, Upton Allen, Michael Green, Douglas Farmer, Eyal Shemesh, Ruth A. McDonald – 9 July 2013

Segment 4 architecture and proposed parenchyma‐wise technique for Ex vivo graft procurement and implantation

Ramadan M. Gharbawy, Bakr M. Nour – 9 July 2013 – A parenchyma‐wise technique for the ex vivo procurement of segment 4 (S4) grafts, based on the detailed architecture of the segment, is proposed. Eighteen normal, fresh livers from adult cadavers were injected differentially with colored latex; dissection casts were prepared; and the intricate architecture of S4 was studied.

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