Prothrombotic factors and nonalcoholic fatty liver disease: An additional link to cardiovascular risk?
Francisco Barrera, Jacob George – 20 June 2013
Adaptation of iron transport and metabolism to acute high‐altitude hypoxia in mountaineers
Oliver Goetze, Johannes Schmitt, Kerstin Spliethoff, Igor Theurl, Günter Weiss, Dorine W. Swinkels, Harold Tjalsma, Marco Maggiorini, Pierre Krayenbühl, Monika Rau, Heiko Fruehauf, Kacper A. Wojtal, Beat Müllhaupt, Michael Fried, Max Gassmann, Thomas Lutz, Andreas Geier – 20 June 2013 – Human iron homeostasis is regulated by intestinal iron transport, hepatic hepcidin release, and signals from pathways that consume or supply iron.
Expanding access to hepatitis C virus care: A call to deconstruct individualized therapy
Andrew Aronsohn, Donald Jensen – 20 June 2013
Dysfunctional CD39POS regulatory T cells and aberrant control of T‐helper type 17 cells in autoimmune hepatitis
Charlotte R. Grant, Rodrigo Liberal, Beth S. Holder, John Cardone, Yun Ma, Simon C. Robson, Giorgina Mieli‐Vergani, Diego Vergani, Maria Serena Longhi – 20 June 2013 – Autoimmune hepatitis (AIH) is an important cause of severe liver disease and is associated with both quantitative and qualitative regulatory T‐cell (Treg) impairments. Tregs express CD39, an ectonucleotidase responsible for extracellular nucleotide hydrolysis, culminating in the production of immunosuppressive adenosine.
Hepatic‐specific lipin‐1 deficiency exacerbates experimental alcohol‐induced steatohepatitis in mice
Ming Hu, Huquan Yin, Mayurranjan S. Mitra, Xiaomei Liang, Joanne M. Ajmo, Karim Nadra, Roman Chrast, Brian N. Finck, Min You – 20 June 2013 – Lipin‐1 regulates lipid metabolism by way of its function as an enzyme in the triglyceride synthesis pathway and as a transcriptional coregulatory protein and is highly up‐regulated in alcoholic fatty liver disease. In the present study, using a liver‐specific lipin‐1‐deficient (lipin‐1LKO) mouse model, we aimed to investigate the functional role of lipin‐1 in the development of alcoholic steatohepatitis and explore the underlying mechanisms.
Hepatic myofibroblasts promote the progression of human cholangiocarcinoma through activation of epidermal growth factor receptor
Audrey Clapéron, Martine Mergey, Lynda Aoudjehane, Thanh Huong Nguyen Ho‐Bouldoires, Dominique Wendum, Aurélie Prignon, Fatiha Merabtene, Delphine Firrincieli, Christèle Desbois‐Mouthon, Olivier Scatton, Filomena Conti, Chantal Housset, Laura Fouassier – 20 June 2013 – Intrahepatic cholangiocarcinoma (CCA) is characterized by an abundant desmoplastic environment.
Epigenetic silencing of DACH1 induces loss of transforming growth factor‐β1 antiproliferative response in human hepatocellular carcinoma
Hongbin Zhu, Kongming Wu, Wenji Yan, Ling Hu, Jing Yuan, Yan Dong, Yazhuo Li, Kunyu Jing, Yunsheng Yang, Mingzhou Guo – 20 June 2013 – Human dachshund homolog 1 (DACH1) is a major component of the Retinal Determination Gene Network (RDGN) and functions as a tumor suppressor. However, the regulation of DACH1 expression and its function in hepatocellular carcinoma (HCC) remain unclear. In this study, epigenetic changes of DACH1 were analyzed in HCC cell lines and primary cancers.
Wnt drives stem cell‐mediated repair response after hepatic injury
Kari N. Nejak‐Bowen, Satdarshan P.S. Monga – 20 June 2013
Prothrombotic factors and nonalcoholic fatty liver disease: An additional link to cardiovascular risk?
Francisco Barrera, Jacob George – 20 June 2013
Growth and development of a new subspecialty: Pediatric hepatology
William F. Balistreri – 20 June 2013 – Several major forces converged to catalyze the formal emergence of a body of knowledge and an organized focus on disorders of the liver in early life. Attendant to the development of a focused clinical subspecialty the pace of patient‐ and laboratory‐based research in the field quickened in parallel to decipher the consequences of genetic or metabolic aberrations on immature liver structure and function.