Postprogression survival of patients with advanced hepatocellular carcinoma: Rationale for second‐line trial design
Maria Reig, Jordi Rimola, Ferran Torres, Anna Darnell, Carlos Rodriguez‐Lope, Alejandro Forner, Neus LLarch, José Ríos, Carmen Ayuso, Jordi Bruix – 20 June 2013 – Sorafenib improves overall survival (OS) of patients with hepatocellular carcinoma (HCC) in the absence of objective response. Thus, time to tumor progression (TTP) is used to capture benefits of novel molecular agents, but proof of its surrogacy with survival is lacking.