Victor I. Machicao, Maya Balakrishnan, Michael B. Fallon – 2 October 2013 – The association of chronic liver disease with respiratory symptoms and hypoxia is well recognized. Over the last century, three pulmonary complications specific to chronic liver disease have been characterized: hepatopulmonary syndrome (HPS), portopulmonary hypertension (POPH), and hepatic hydrothorax (HH). The development of portal hypertension is fundamental in the pathogenesis of each of these disorders.

Alphonse E. Sirica, Gregory J. Gores – 2 October 2013

Alphonse E. Sirica, Gregory J. Gores – 2 October 2013

Isaac T.W. Harley, Traci E. Stankiewicz, Daniel A. Giles, Samir Softic, Leah M. Flick, Monica Cappelletti, Rachel Sheridan, Stavra A. Xanthakos, Kris A. Steinbrecher, R. Balfour Sartor, Rohit Kohli, Christopher L. Karp, Senad Divanovic – 2 October 2013 – Inflammation plays a central pathogenic role in the pernicious metabolic and end‐organ sequelae of obesity. Among these sequelae, nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in the developed world.

Victor I. Machicao, Maya Balakrishnan, Michael B. Fallon – 2 October 2013 – The association of chronic liver disease with respiratory symptoms and hypoxia is well recognized. Over the last century, three pulmonary complications specific to chronic liver disease have been characterized: hepatopulmonary syndrome (HPS), portopulmonary hypertension (POPH), and hepatic hydrothorax (HH). The development of portal hypertension is fundamental in the pathogenesis of each of these disorders.

John Denis Ryan, Sandro Altamura, Martina Muckenthaler, John Crowe – 1 October 2013

Iryna Zubkova, Hongying Duan, Frances Wells, Howard Mostowski, Esther Chang, Kathleen Pirollo, Kris Krawczynski, Robert Lanford, Marian Major – 1 October 2013 – Vaccination of chimpanzees against hepatitis C virus (HCV) using T‐cell‐based vaccines targeting nonstructural proteins has not resulted in the same levels of control and clearance as those seen in animals reexposed after HCV clearance. We hypothesized that the outcome of infection depends on the different subtypes of activated T cells.

Donald B. Smith, Jens Bukh, Carla Kuiken, A. Scott Muerhoff, Charles M. Rice, Jack T. Stapleton, Peter Simmonds – 1 October 2013 – The 2005 consensus proposal for the classification of hepatitis C virus (HCV) presented an agreed and uniform nomenclature for HCV variants and the criteria for their assignment into genotypes and subtypes. Since its publication, the available dataset of HCV sequences has vastly expanded through advancement in nucleotide sequencing technologies and an increasing focus on the role of HCV genetic variation in disease and treatment outcomes.

1 October 2013

1 October 2013