Antiviral treatment for hepatitis C virus infection is associated with improved renal and cardiovascular outcomes in diabetic patients

Yao‐Chun Hsu, Jaw‐Town Lin, Hsiu J. Ho, Yu‐Hsi Kao, Yen‐Tsung Huang, Nai‐Wan Hsiao, Ming‐Shiang Wu, Yi‐Ya Liu, Chun‐Ying Wu – 12 October 2013 – Hepatitis C virus (HCV) infection is causally associated with insulin resistance and diabetes mellitus. This population‐based cohort study aimed to investigate whether antiviral therapy for HCV infection was associated with improved clinical outcomes related to diabetes. From the Taiwan National Health Insurance Research Database, 2,267,270 Taiwanese residents diagnosed with diabetes mellitus were screened for eligibility.

Epitope‐optimized alpha‐fetoprotein genetic vaccines prevent carcinogen‐induced murine autochthonous hepatocellular carcinoma

Yuan Hong, Yibing Peng, Z. Sheng Guo, Jose Guevara‐Patino, Junfeng Pang, Lisa H. Butterfield, Nahid F. Mivechi, David H. Munn, David L. Bartlett, Yukai He – 12 October 2013 – Immunization with effective cancer vaccines can offer a much needed adjuvant therapy to fill the treatment gap after liver resection to prevent relapse of hepatocellular carcinoma (HCC). However, current HCC cancer vaccines are mostly based on native shared‐self/tumor antigens that are only able to induce weak immune responses.

Peroxisome proliferator‐activated receptor α activates human multidrug resistance transporter 3/ATP‐binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion

Nisanne S. Ghonem, Meenakshisundaram Ananthanarayanan, Carol J. Soroka, James L. Boyer – 12 October 2013 – Multidrug resistance transporter 3/ATP‐binding cassette protein subfamily B4 (MDR3/ABCB4) is a critical determinant of biliary phosphatidylcholine (PC) secretion. Clinically, mutations and partial deficiencies in MDR3 result in cholestatic liver injury. Thus, MDR3 is a potential therapeutic target for cholestatic liver disease. Fenofibrate is a peroxisome proliferator‐activated receptor (PPAR) α ligand that has antiinflammatory actions and regulates bile acid detoxification.

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