Pharmacological inhibition of the chemokine C‐C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly‐6C+ macrophage infiltration in mice

Christer Baeck, Xiao Wei, Matthias Bartneck, Viktor Fech, Felix Heymann, Nikolaus Gassler, Kanishka Hittatiya, Dirk Eulberg, Tom Luedde, Christian Trautwein, Frank Tacke – 8 October 2013 – Macrophages constitute a major proinflammatory component during chronic liver diseases and are considered a key factor in promoting hepatic fibrosis. However, there is increasing evidence that distinct monocyte and macrophage subsets exert critical functions in regression from organ fibrosis as well.

Tri‐iodothyronine induces hepatocyte proliferation by protein kinase a‐dependent β‐catenin activation in rodents

Maura Fanti, Sucha Singh, Giovanna M. Ledda‐Columbano, Amedeo Columbano, Satdarshan P. Monga – 7 October 2013 – Thyroid hormone (T3), like many other ligands of the steroid/thyroid hormone nuclear receptor superfamily, is a strong inducer of liver cell proliferation in rats and mice. However, the molecular basis of its mitogenic activity, which is currently unknown, must be elucidated if its use in hepatic regenerative medicine is to be considered. F‐344 rats or C57BL/6 mice were fed a diet containing T3 for 2‐7 days.

Ascites and serum sodium are markers of increased waiting list mortality in children with chronic liver failure

Renata Pugliese, Eduardo A. Fonseca, Gilda Porta, Vera Danesi, Teresa Guimaraes, Adriana Porta, Irene K. Miura, Cristian Borges, Helry Candido, Marcel Benavides, Flavia H. Feier, Andre Godoy, Rita Antonelli Cardoso, Mario Kondo, Paulo Chapchap, Joao Seda Neto – 7 October 2013 – Ascites is the most common complication of cirrhosis and in adults it is associated with 50% mortality at 5 years if patients do not receive a liver transplant. The occurrence of hyponatremia in these patients has been associated with increased mortality on the waiting list.

Hemodynamic changes in the hepatic circulation after the modulation of the splenic circulation in an in vivo human experimental model

Nobuhisa Akamatsu, Yasuhiko Sugawara, Shouichi Satou, Tetsuya Mitsui, Riki Ninomiya, Masahiko Komagome, Fumiaki Ozawa, Yoshifumi Beck – 4 October 2013 – Recent advances in liver surgery have highlighted the effects of the splenic circulation on the hepatic circulation with respect to the hepatic arterial buffer response (HABR). The aim of the present study was to investigate the actual hemodynamic effects of splenic artery embolization/ligation and splenectomy on the hepatic circulation in patients who underwent pancreaticoduodenectomy through in vivo experimental models.

Hepatitis E infection in liver transplant recipients

Alberto Unzueta, Jorge Rakela – 4 October 2013 – Hepatitis E virus (HEV) infection (genotype 3) has been described in developed countries as a cause of chronic hepatitis in recipients of solid organ transplantation (SOT), with the first cases reported in 2008. Immunosuppression seems to play a major role in the pathogenesis of chronic infections. The current gold standard for the diagnosis of HEV infection is the detection of HEV RNA in serum, stools, or both.

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