Donation after cardiac death liver transplantation: Graft quality evaluation based on pretransplant liver biopsy

Weiliang Xia, Qinghong Ke, Ye Wang, Xiaowen Feng, Haijun Guo, Weilin Wang, Min Zhang, Yan Shen, Jian Wu, Xiao Xu, Sheng Yan, Shusen Zheng – 30 March 2015 – Donation after cardiac death (DCD) liver grafts are associated with inferior clinical outcomes and high discard rates because of poor graft quality. We investigated the predictive value of DCD liver biopsy for the pretransplant graft quality evaluation. DCD liver transplants that took place between October 2010 and April 2014 were included (n = 127).

Sofosbuvir and simeprevir for treatment of hepatitis C virus infection in liver transplant recipients

Julio A. Gutierrez, Andres F. Carrion, Danny Avalos, Christopher O'Brien, Paul Martin, Kalyan Ram Bhamidimarri, Adam Peyton – 30 March 2015 – Recurrent hepatitis C virus (HCV) infection occurs universally in the allograft in the absence of effective antiviral therapy before liver transplantation (LT). Antiviral therapy with sofosbuvir and simeprevir has proven to be highly effective and well tolerated in the nontransplant setting for treatment of HCV genotype 1 infection; therefore, we sought to evaluate the efficacy and safety of this regimen in LT recipients with recurrent HCV infection.

Human neonatal hepatocyte transplantation induces long‐term rescue of unconjugated hyperbilirubinemia in the Gunn rat

Laia Tolosa, Silvia López, Eugenia Pareja, María Teresa Donato, Anne Myara, Tuan Huy Nguyen, José Vicente Castell, María José Gómez‐Lechón – 30 March 2015 – Crigler‐Najjar type 1 disease is a rare inherited metabolic disease characterized by high levels of unconjugated bilirubin due to the complete absence of hepatic uridine diphosphoglucuronate–glucuronosyltransferase activity. Hepatocyte transplantation (HT) has been proposed as an alternative treatment for Crigler‐Najjar syndrome, but it is still limited by the quality and the low engraftment and repopulation ability of the cells used.

Comparison between minimally invasive and open living donor hepatectomy: A systematic review and meta‐analysis

Giammauro Berardi, Federico Tomassini, Roberto Ivan Troisi – 30 March 2015 – Living donor liver transplantation is a valid alternative to deceased donor liver transplantation, and its safety and feasibility have been well determined. Minimally invasive living donor hepatectomy (MILDH) has taken some time to be accepted because of inherent technical difficulties and the highly demanding surgical skills needed to perform the procedure, and its role is still being debated.

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