Silvia Udali, Patrizia Guarini, Sara Moruzzi, Andrea Ruzzenente, Stephanie A. Tammen, Alfredo Guglielmi, Simone Conci, Patrizia Pattini, Oliviero Olivieri, Roberto Corrocher, Sang‐Woon Choi, Simonetta Friso – 1 April 2015 – In addition to DNA methylation, hydroxymethylation of DNA is recognized as a novel epigenetic mark. Primary liver cancers, i.e., hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC), are highly prevalent but epigenetically poorly characterized, so far.

Juling Ji, Tobias Eggert, Anuradha Budhu, Marshonna Forgues, Atsushi Takai, Hien Dang, Qinghai Ye, Ju‐Seog Lee, Ji Hoon Kim, Tim F. Greten, Xin Wei Wang – 1 April 2015 – Hepatocellular carcinoma (HCC) patients suffer from a poor survival rate and a high incidence of postoperative recurrence. The hepatic microenvironment plays a significant role in the initiation, progression, and recurrence of HCC; however, the causal mechanisms of these phenomena are unclear.

Mette Vesterhus, Johannes Roksund Hov, Anders Holm, Erik Schrumpf, Ståle Nygård, Kristin Godang, Ina Marie Andersen, Sigrid Næss, Douglas Thorburn, Francesca Saffioti, Morten Vatn, Odd Helge Gilja, Fridtjof Lund‐Johansen, Trygve Syversveen, Knut Brabrand, Albert Parés, Cyriel Y. Ponsioen, Massimo Pinzani, Martti Färkkilä, Bjørn Moum, Thor Ueland, Helge Røsjø, William Rosenberg, Kirsten Muri Boberg, Tom H. Karlsen – 1 April 2015 – There is a need to determine biomarkers reflecting disease activity and prognosis in primary sclerosing cholangitis (PSC).

Zhen Yang, Xiaodan Zhang, Rosebud O. Roberts, Lewis R. Roberts, Roongruedee Chaiteerakij – 1 April 2015

Jack Uetrecht, Neil Kaplowitz – 1 April 2015

1 April 2015

Rajagopal N. Aravalli, John D. Belcher, Clifford J. Steer – 30 March 2015 – The liver plays a major role in many inherited and acquired genetic disorders. It is also the site for the treatment of certain inborn errors of metabolism that do not directly cause injury to the liver. The advancement of nucleic acid–based therapies for liver maladies has been severely limited because of the myriad untoward side effects and methodological limitations.

Tommaso Di Maira, Angel Rubin, Lorena Puchades, Victoria Aguilera, Carmen Vinaixa, Maria Garcia, Nicola De Maria, Erica Villa, Rafael Lopez‐Andujar, Fernando San Juan, Eva Montalva, Judith Perez, Martin Prieto, Marina Berenguer – 30 March 2015 – Cardiovascular (CV) events represent major impediments to the long‐term survival of liver transplantation (LT) patients. The aim of this study was to assess whether the Framingham risk score (FRS) at transplantation can predict the development of post‐LT cardiovascular events (CVEs). Patients transplanted between 2006 and 2008 were included.

Nis Hallundbæk Schlesinger, Peter Svenningsen, Susanne Frevert, André Wettergren, Jens Hillingsø – 30 March 2015 – Bile duct stones and casts (BDSs) contribute importantly to morbidity after liver transplantation (LT). The purpose of this study was to estimate the clinical efficacy, safety, and long‐term results of percutaneous transhepatic cholangioscopic lithotripsy (PTCSL) in transplant recipients and to discuss underlying factors affecting the outcome.

Giuseppina Basta, Serena Del Turco, Teresa Navarra, William M. Lee, Acute Liver Failure Study Group – 30 March 2015 – Animal studies suggest that receptor for advanced glycation end products (RAGE)–dependent mechanisms contribute to acetaminophen‐induced liver damage.