Con: Acute‐on‐chronic liver failure
John O'Grady – 26 June 2017
Disparities in Eurotransplant liver transplantation wait‐list outcome between patients with and without model for end‐stage liver disease exceptions
Andreas Umgelter, Alexander Hapfelmeier, Wouter Kopp, Marieke van Rosmalen, Xavier Rogiers, Markus Guba, for the Eurotransplant Liver Advisory Committee – 26 June 2017 – The sickest‐first principle in donor‐liver allocation can be implemented by allocating organs to patients with cirrhosis with the highest Model for End‐Stage Liver Disease (MELD) scores. For patients with other risk factors, standard exceptions (SEs) and nonstandard exceptions (NSEs) have been developed.
Alcohol abstinence in patients surviving an episode of alcoholic hepatitis: Prediction and impact on long‐term survival
José Altamirano, Hugo López‐Pelayo, Javier Michelena, Patricia D. Jones, Lluisa Ortega, Pere Ginès, Juan Caballería, Antoni Gual, Ramón Bataller, Anna Lligoña – 23 June 2017 – Alcoholic hepatitis (AH) is the most severe form of alcoholic liver disease. Most studies have focused on short‐term prognosis, whereas factors associated with long‐term survival are largely unknown.
Healthy controls in nonalcoholic fatty liver disease management: A biomedical research perspective
Saumya Pandey – 23 June 2017
Argininosuccinate synthase 1 (ASS1): A marker of unclassified hepatocellular adenoma and high bleeding risk
Elodie Henriet, Aya Abou Hammoud, Jean‐William Dupuy, Benjamin Dartigues, Zakaria Ezzoukry, Nathalie Dugot‐Senant, Thierry Leste‐Lasserre, Nestor Pallares‐Lupon, Macha Nikolski, Brigitte Le Bail, Jean‐Frédéric Blanc, Charles Balabaud, Paulette Bioulac‐Sage, Anne‐Aurélie Raymond, Frédéric Saltel – 23 June 2017 – Hepatocellular adenomas (HCAs) are rare benign tumors divided into three main subgroups defined by pathomolecular features, HNF1A (H‐HCA), mutated β‐catenin (b‐HCA), and inflammatory (IHCA).
Hepatic stimulator substance resists hepatic ischemia/reperfusion injury by regulating Drp1 translocation and activation
Chao Zhang, Jing Huang, Wei An – 23 June 2017 – Ischemia/reperfusion injury, induced by abnormal mitochondrial fission–related apoptosis, is a major concern in liver transplantation settings. Our previous studies have demonstrated that hepatic stimulator substance (HSS) is an antiapoptotic effector and could protect liver from ischemia/reperfusion injury. However, the underlying mechanism remains unclear.
The liver–gut microbiota axis modulates hepatotoxicity of tacrine in the rat
Lian Yee Yip, Chiu Cheong Aw, Sze Han Lee, Yi Shuen Hong, Han Chen Ku, Winston Hecheng Xu, Jessalyn Mei Xuan Chan, Eleanor Jing Yi Cheong, Kern Rei Chng, Amanda Hui Qi Ng, Niranjan Nagarajan, Ratha Mahendran, Yuan Kun Lee, Edward R. Browne, Eric Chun Yong Chan – 23 June 2017 – The gut microbiota possesses diverse metabolic activities, but its contribution toward heterogeneous toxicological responses is poorly understood. In this study, we investigated the role of the liver–gut microbiota axis in underpinning the hepatotoxicity of tacrine.
Targeting histone deacetylase 4/ubiquitin‐conjugating enzyme 9 impairs DNA repair for radiosensitization of hepatocellular carcinoma cells in mice
Chiao‐Ling Tsai, Wei‐Lin Liu, Feng‐Ming Hsu, Po‐Sheng Yang, Ruoh‐Fang Yen, Kai‐Yuan Tzen, Ann‐Lii Cheng, Pei‐Jer Chen, Jason Chia‐Hsien Cheng – 23 June 2017 – Several strategies to improve the efficacy of radiation therapy against hepatocellular carcinoma (HCC) have been investigated. One approach is to develop radiosensitizing compounds.
Prospero‐related homeobox 1 drives angiogenesis of hepatocellular carcinoma through selectively activating interleukin‐8 expression
Yanfeng Liu, Yonglong Zhang, Shenghao Wang, Qiong‐Zhu Dong, Zhongliang Shen, Wei Wang, Shuai Tao, Chenjian Gu, Jing Liu, Youhua Xie, Lun‐Xiu Qin – 23 June 2017 – Angiogenesis has been proven to play an important role in the progression of hepatocellular carcinoma (HCC). However, the molecular mechanism underlying HCC angiogenesis is not well understood. In this study, Prospero‐related homeobox 1 (PROX1) was identified as a novel proangiogenic factor in HCC cell lines and tissues. A strong positive correlation was found between the levels of PROX1 and microvessel density in HCC tissues.