The emergence of NS5B resistance associated substitution S282T after sofosbuvir‐based treatment

Edward J. Gane, Sophie Metivier, Ronald Nahass, Michael Ryan, Catherine A. Stedman, Evguenia S. Svarovskaia, Hongmei Mo, Brian Doehle, Hadas Dvory‐Sobol, Charlotte Hedskog, Ming Lin, Diana M. Brainard, Jenny C. Yang, John G. McHutchison, Mark Sulkowski, Ziad Younes, Eric Lawitz – 22 June 2017 – S282T in NS5B is the primary amino acid substitution associated with resistance to sofosbuvir (SOF) but has rarely been detected in patients treated with a SOF‐based regimen.

A liver‐specific gene expression panel predicts the differentiation status of in vitro hepatocyte models

Dae‐Soo Kim, Jea‐Woon Ryu, Mi‐Young Son, Jung‐Hwa Oh, Kyung‐Sook Chung, Sugi Lee, Jeong‐Ju Lee, Jun‐Ho Ahn, Ju‐Sik Min, Jiwon Ahn, Hyun Mi Kang, Janghwan Kim, Cho‐Rok Jung, Nam‐Soon Kim, Hyun‐Soo Cho – 22 June 2017 – Alternative cell sources, such as three‐dimensional organoids and induced pluripotent stem cell–derived cells, might provide a potentially effective approach for both drug development applications and clinical transplantation.

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