Fu‐Ming Chang, Yen‐Po Wang, Ching‐Liang Lu – 24 November 2017

Mengnuo Chen, Lai Wei, Cheuk‐Ting Law, Felice Ho‐Ching Tsang, Jialing Shen, Carol Lai‐Hung Cheng, Long‐Hin Tsang, Daniel Wai‐Hung Ho, David Kung‐Chun Chiu, Joyce Man‐Fong Lee, Carmen Chak‐Lui Wong, Irene Oi‐Lin Ng, Chun‐Ming Wong – 24 November 2017 – Epigenetic alterations have contributed greatly to human carcinogenesis. Conventional epigenetic studies have predominantly focused on DNA methylation, histone modifications, and chromatin remodeling. Recently, diverse and reversible chemical modifications of RNAs have emerged as a new layer of epigenetic regulation.

Suzane Kioko Ono, Leda Bassit, Victor Van Vaisberg, Venâncio Avancini Ferreira Alves, Elia G. Caldini, Brian D. Herman, Reed Shabman, Nadia B. Fedorova, Denise Paranaguá‐Vezozzo, Caroline Torres Sampaio, Rafael Bandeira Lages, Débora Terrabuio, Wellington Andraus, Raymond F. Schinazi, Flair José Carrilho – 24 November 2017

Gin‐Ho Lo, Thomas Reiberger – 23 November 2017

Andrija Matak, Pooja Lahiri, Ethan Ford, Daniela Pabst, Karl Kashofer, Dimitris Stellas, Dimitris Thanos, Kurt Zatloukal – 23 November 2017 – Intratumor heterogeneity is increasingly recognized as a major factor impacting diagnosis and personalized treatment of cancer. We characterized stochastic phenotype switching as a mechanism contributing to intratumor heterogeneity and malignant potential of liver cancer.

Jei‐Ming Peng, Rabindranath Bera, Chih‐Yung Chiou, Ming‐Chin Yu, Tse‐Chin Chen, Chia‐Wei Chen, Tsung‐Rui Wang, Wan‐Ling Chiang, Shin‐Pei Chai, Yongkun Wei, Huamin Wang, Mien‐Chie Hung, Sen‐Yung Hsieh – 23 November 2017 – High invasiveness is a hallmark of human hepatocellular carcinoma (HCC). Large tumors predict invasion and metastasis. Epithelial‐mesenchymal transition (EMT) is crucial for cancer invasion and metastasis. However, the mechanisms whereby large tumors tend to undergo EMT remain unclear.

Andrija Matak, Pooja Lahiri, Ethan Ford, Daniela Pabst, Karl Kashofer, Dimitris Stellas, Dimitris Thanos, Kurt Zatloukal – 23 November 2017 – Intratumor heterogeneity is increasingly recognized as a major factor impacting diagnosis and personalized treatment of cancer. We characterized stochastic phenotype switching as a mechanism contributing to intratumor heterogeneity and malignant potential of liver cancer.

Jingying Zhang, Qi Zhang, Yu Lou, Qihan Fu, Qi Chen, Tao Wei, Jiaqi Yang, Jinlong Tang, Jianxin Wang, Yiwen Chen, Xiaoyu Zhang, Jian Zhang, Xueli Bai, Tingbo Liang – 23 November 2017 – The development and progression of hepatocellular carcinoma (HCC) are dependent on its local microenvironment. Hypoxia and inflammation are two critical factors that shape the HCC microenvironment; however, the interplay between the two factors and the involvement of cancer cells under such conditions remain poorly understood.

Mauro Borzio, Elena Dionigi, Angelo Rossini, Massimo Marignani, Rodolfo Sacco, Ilario De Sio, Emanuela Bertolini, Giampiero Francica, Anna Giacomin, Giancarlo Parisi, Susanna Vicari, Anna Toldi, Andrea Salmi, Sergio Boccia, Mario Mitra, Fabio Fornari – 22 November 2017 – Several staging systems for hepatocellular carcinoma (HCC) have been developed. The Barcelona Clinic Liver Cancer staging system is considered the best in predicting survival, although limitations have emerged.

Mauro Borzio, Elena Dionigi, Angelo Rossini, Massimo Marignani, Rodolfo Sacco, Ilario De Sio, Emanuela Bertolini, Giampiero Francica, Anna Giacomin, Giancarlo Parisi, Susanna Vicari, Anna Toldi, Andrea Salmi, Sergio Boccia, Mario Mitra, Fabio Fornari – 22 November 2017 – Several staging systems for hepatocellular carcinoma (HCC) have been developed. The Barcelona Clinic Liver Cancer staging system is considered the best in predicting survival, although limitations have emerged.