CD36 deficiency attenuates immune‐mediated hepatitis in mice by modulating the proapoptotic effects of CXC chemokine ligand 10

Che Xu, Chen Zhang, Jie Ji, Chao Wang, Jing Yang, Biao Geng, Ting Zhao, Hong Zhou, Xianmin Mu, Jinshun Pan, Shi Hu, Yuanfang Lv, Xingguo Chen, Hao Wen, Qiang You – 8 December 2017 – The scavenger receptor CD36 recognizes a diverse set of ligands and has been implicated in a wide variety of normal and pathological processes, including lipid metabolism, angiogenesis, atherosclerosis, and phagocytosis. In particular, recent findings have demonstrated its crucial functions in sterile inflammation and tumor metastasis. However, the role of CD36 in immune‐mediated hepatitis remains unclear.

Significance and mechanism of androgen receptor overexpression and androgen receptor/mechanistic target of rapamycin cross‐talk in hepatocellular carcinoma

Hong Zhang, Xiao‐Xing Li, Yang Yang, Yanjie Zhang, Hui‐Yun Wang, X.F. Steven Zheng – 8 December 2017 – Hepatocellular carcinoma (HCC) is a male‐dominant cancer, and androgen receptor (AR) has been linked to the pathogenesis of HCC. However, AR expression and its precise role in HCC remain controversial. Moreover, previous antiandrogen and anti‐AR clinical trials in HCC failed to demonstrate clinical benefits. In this study, we found that AR is overexpressed in the nucleus of approximately 37% of HCC tumors, which is significantly associated with advanced disease stage and poor survival.

Milder disease stage in patients with primary biliary cholangitis over a 44‐year period: A changing natural history

Carla F. Murillo Perez, Jorn C. Goet, Willem J. Lammers, Aliya Gulamhusein, Henk R. van Buuren, Cyriel Y. Ponsioen, Marco Carbone, Andrew Mason, Christophe Corpechot, Pietro Invernizzi, Marlyn J. Mayo, Pier Maria Battezzati, Annarosa Floreani, Albert Pares, Frederik Nevens, Kris V. Kowdley, Tony Bruns, George N. Dalekos, Douglas Thorburn, Gideon Hirschfield, Nicholas F. LaRusso, Keith D. Lindor, Kalliopi Zachou, Raoul Poupon, Palak J. Trivedi, Xavier Verhelst, Harry L.A. Janssen, Bettina E.

Impact of aberrant left hepatic artery ligation on the outcome of liver transplantation

Roberto Montalti, Andrea Benedetti Cacciaguerra, Daniele Nicolini, Emad Alì Ahmed, Martina Coletta, Lesley De Pietri, Andrea Risaliti, Roberto Ivan Troisi, Federico Mocchegiani, Marco Vivarelli – 6 December 2017 – The preservation of a graft's aberrant left hepatic artery (LHA) during liver transplantation (LT) ensures optimal vascularization of the left liver but can also be considered a risk factor for hepatic artery thrombosis (HAT). In contrast, ligation of an aberrant LHA may lead to hepatic ischemia with the potential risk of graft dysfunction and biliary complications.

Decellularized human placenta supports hepatic tissue and allows rescue in acute liver failure

Zurab Kakabadze, Ann Kakabadze, David Chakhunashvili, Lia Karalashvili, Ekaterine Berishvili, Yogeshwar Sharma, Sanjeev Gupta – 6 December 2017 – Tissue engineering with scaffolds to form transplantable organs is of wide interest. Decellularized tissues have been tested for this purpose, although supplies of healthy donor tissues, vascular recellularization for perfusion, and tissue homeostasis in engineered organs pose challenges. We hypothesized that decellularized human placenta will be suitable for tissue engineering.

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