Issue Information
4 December 2017
Prediction of histologic alcoholic hepatitis based on clinical presentation limits the need for liver biopsy
Nitzan C. Roth, Behnam Saberi, Jared Macklin, Gary Kanel, Samuel W. French, Sugantha Govindarajan, Anthony S. Buzzanco, Andrew A. Stolz, John A. Donovan, Neil Kaplowitz – 4 December 2017 – The clinical presentation of alcoholic hepatitis (AH) can be mimicked by other alcoholic liver diseases. The aim of this study was to identify clinical features that predict AH on liver biopsy. Biopsies from patients hospitalized for presumed severe AH were used to identify a derivation cohort (101 patients) and validation cohort (71 patients).
Targeting bile acids and lipotoxicity for NASH treatment
John Y. L. Chiang – 4 December 2017
Targeting bile acids and lipotoxicity for NASH treatment
John Y. L. Chiang – 4 December 2017
Gentle palpating liver sinusoidal endothelial cells reveals the dynamic behavior and formation of fenestrae: A new window for biomedical research
Filip Braet, Eddie Wisse – 2 December 2017
The nonalcoholic steatohepatitis metabotype: Imbalance of circulating amino acids and transamination reactions reflect impaired mitochondrial function
Silvia Sookoian, Carlos J. Pirola – 2 December 2017
Reply
Behnam Saberi, Alia S. Dadabhai, Christine M. Durand, Benjamin Philosophe, Andrew M. Cameron, Mark S. Sulkowski, Ahmet Gurakar – 2 December 2017
Hepatitis C transmission from seropositive, nonviremic donors to non–hepatitis C liver transplant recipients
Khurram Bari, Keith Luckett, Tiffany Kaiser, Tayyab Diwan, Madison Cuffy, Michael R. Schoech, Kamran Safdar, Jason T. Blackard, Senu Apewokin, Flavio Paterno, Kenneth E. Sherman, Stephen D. Zucker, Nadeem Anwar, Shimul A. Shah – 2 December 2017 – Breakthroughs in hepatitis C virus (HCV) treatment and rising rates of intravenous drug use have led to an increase in the number of organ donors who are HCV antibody–positive but serum nucleic acid test (NAT)–negative. The risk of HCV transmission from the liver grafts of these donors to recipients is unknown.
The short‐term incidence of hepatocellular carcinoma is not increased after hepatitis C treatment with direct‐acting antivirals: An ERCHIVES study
Darrick K. Li, Yanjie Ren, Daniel S. Fierer, Stephanie Rutledge, Obaid S. Shaikh, Vincent Lo Re, Tracey Simon, Abdul‐Badi Abou‐Samra, Raymond T. Chung, Adeel A. Butt – 2 December 2017 – Recent studies have reported higher rates of hepatocellular carcinoma (HCC) in individuals treated with direct‐acting antivirals (DAAs). However, making definitive conclusions has been challenging because of the heterogeneous populations and methodologies of these reports.
Thoracic epidural analgesia in donor hepatectomy: An analysis
Archna Koul, Deepanjali Pant, Swetha Rudravaram, Jayashree Sood – 2 December 2017 – The purpose of this study is to analyze whether supplementation of general anesthesia (GA) with thoracic epidural analgesia (TEA) for right lobe donor hepatectomy is a safe modality of pain relief in terms of changes in postoperative coagulation profile, incidence of epidural catheter–related complications, and timing of removal of epidural catheter. Retrospective analysis of the record of 104 patients who received TEA for right lobe donor hepatectomy was done.