Roslin Y. Docta, Tiago Ferronha, Joseph P. Sanderson, Thomas Weissensteiner, George R. Pope, Alan D. Bennett, Nicholas J. Pumphrey, Zoltan Ferjentsik, Laura L. Quinn, Guy E. Wiedermann, Victoria E. Anderson, Manoj Saini, Miguel Maroto, Elliot Norry, Andrew B. Gerry – 18 December 2018 – Patients with hepatocellular carcinoma (HCC) have a poor prognosis and limited therapeutic options. Alpha‐fetoprotein (AFP) is often expressed at high levels in HCC and is an established clinical biomarker of the disease.

Derek Lee, Iris Ming‐Jing Xu, David Kung‐Chun Chiu, Josef Leibold, Aki Pui‐Wah Tse, Macus Hao‐Ran Bao, Vincent Wai‐Hin Yuen, Cerise Yuen‐Ki Chan, Robin Kit‐Ho Lai, Don Wai‐Ching Chin, Daniel For‐Fan Chan, Tan‐To Cheung, Siu‐Ho Chok, Chun‐Ming Wong, Scott W. Lowe, Irene Oi‐Lin Ng, Carmen Chak‐Lui Wong – 18 December 2018 – Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal cancers worldwide which lacks effective treatment. Cancer cells experience high levels of oxidative stress due to increased generation of reactive oxygen species (ROS).

Samer Chehade, Paul C. Adams – 18 December 2018

Wayel Jassem, Emmanuel Xystrakis, Yasmeen G. Ghnewa, Muhammed Yuksel, Oltin Pop, Marc Martinez‐Llordella, Yamen Jabri, Xiaohong Huang, Juan J. Lozano, Alberto Quaglia, Alberto Sanchez‐Fueyo, Constantin C. Coussios, Mohamed Rela, Peter Friend, Nigel Heaton, Yun Ma – 18 December 2018 – Liver transplantation (LT) is a successful treatment for patients with liver failure. However, organ shortage results in over 11% of patients losing their chance of a transplant attributed to liver decompensation (LD) and death.

Jiaye Liu, Tao Li, Li Zhang, Aiqiang Xu – 18 December 2018 – In actual clinical practice, infinite nucleos(t)ide analogues (NAs) treatment for chronic hepatitis B virus (HBV) infection is unrealistic. The most commonly used endpoint is suppression of HBV DNA to undetectable levels with normalization of alanine aminotransferase. However, this criterion for cessation of treatment is associated with various incidences of virological and clinical relapse.

Steven F. Solga, Marina Serper, Rebecca A. Young, Kimberly A. Forde – 18 December 2018 – Early liver transplantation for alcoholic hepatitis is a potentially life‐saving treatment. As this practice becomes increasingly common, however, the liver transplant community is taking a fresh look at a familiar challenge: best stewardship of donor organs. Herein, we examine a few basic, necessary ethical and practical concerns relevant to this indication.

Samer Chehade, Paul C. Adams – 18 December 2018

Jiaye Liu, Tao Li, Li Zhang, Aiqiang Xu – 18 December 2018 – In actual clinical practice, infinite nucleos(t)ide analogues (NAs) treatment for chronic hepatitis B virus (HBV) infection is unrealistic. The most commonly used endpoint is suppression of HBV DNA to undetectable levels with normalization of alanine aminotransferase. However, this criterion for cessation of treatment is associated with various incidences of virological and clinical relapse.

Mar Riveiro‐Barciela, Merche Gironella, Alicia Senín, María‐Teresa Salcedo, Xavier Merino‐Casabiel, Lluis Castells, Rafael Esteban, Maria Buti, Fernando Martínez‐Valle – 18 December 2018

Beatriz Aguilar‐Bravo, Daniel Rodrigo‐Torres, Silvia Ariño, Mar Coll, Elisa Pose, Delia Blaya, Isabel Graupera, Luis Perea, Júlia Vallverdú, Teresa Rubio‐Tomás, Laurent Dubuquoy, Carolina Armengol, Antonio Lo Nigro, Peter Stärkel, Philippe Mathurin, Ramon Bataller, Joan Caballería, Juan José Lozano, Pere Ginès, Pau Sancho‐Bru – 18 December 2018 – Chronic liver diseases are characterized by the expansion of ductular reaction (DR) cells and the expression of liver progenitor cell (LPC) markers.